Apoptosis time window induced by cold atmospheric plasma: Comparison with ionizing radiation
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Filipović Tričković, Jelena G.
Malović, Gordana N.
Petrović, Zoran Lj.
Article (Published version)
© 2019, Indian Academy of Sciences
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In this study we evaluate apoptosis time window of primary fibroblasts treated with cold atmospheric plasma (CAP), power range 0.4-1.4 W, for 30 sec, using γ-H2AX phosphorylation assay and flow cytometry. In contrast to irradiation where maximum of γ-H2AX foci appeared 30 min after irradiation and apoptosis 24 h later irrespective of radiation dose, treatment with CAP (power of 0.4 and 0.6) induces maximum of γ-H2AX foci 2 h after treatment. Apoptosis occurred in a power-dependent manner, with time shift of 2-3 h. Besides power-dependent time shift in apoptosis induction, apoptosis time window is the same and lasts for 2 h. © 2019, Indian Academy of Sciences.
Keywords:Apoptosis / cold atmospheric plasma / ionizing radiation / primary human fibroblasts / repair kinetics
Source:Current Science, 2019, 116, 7, 1229-1233
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