Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma
Аутори
Latić, DraganaPejić, Snežana
Savić, Slaviša
Lončar, Zlatibor
Nikolić, Ivan M.
Nikolić, Gorana V.
Pavlović, Ivan
Radojević-Škodrić, Sanja
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Purpose: There is a need for identifying molecular prognostic biomarkers to better predict clinical outcomes in patients with renal cell carcinoma (RCC). This study investigated the pattern of cyclin D1 and p57 expression in RCC patients and evaluated their relation with clinicopathological characteristics and overall survival (OS). Methods: Immunohistochemistry was applied to paraffin-embedded tissue sections of 74 RCC patients. Two cut-off groups were defined by the fraction of positive cells as fol-lows: ≤10% and >10% positive cells for cyclin D1, and ≤5% and >5% positive cells for p57. Results: Cyclin D1 expression in >10% of positive cells was observed mostly in the clear cell RCC, while p57 expression in ≤5% of positive cells was found in 86% of chromophobe RCC specimens. The higher expression of cyclin D1 and lower expression of p57 were more frequent in grade I-II tumors. OS was associated with unfavorable clinicopathological characteristics. However, cyclin D1/p57 expression d...id not influence the survival rates. Conclusion: Although cyclin D1 and p57 expression did not affect survival rates in RCC patients, proper validation and establishment of the qualitative cut-off point are needed for these tumors.
Кључне речи:
cell cycle proteins / cyclin D1 / immunohistochemistry / renal cell cancer / p57 / survivalИзвор:
Journal of BUON, 2019, 24, 1, 301-309Финансирање / пројекти:
- Оптичко микроскопска, имуноморфолошка, молекуларно-биолошка и генетска испитивања малигних и немалигних болести бубрега (RS-MESTD-Basic Research (BR or ON)-175059)
Колекције
Институција/група
VinčaTY - JOUR AU - Latić, Dragana AU - Pejić, Snežana AU - Savić, Slaviša AU - Lončar, Zlatibor AU - Nikolić, Ivan M. AU - Nikolić, Gorana V. AU - Pavlović, Ivan AU - Radojević-Škodrić, Sanja PY - 2019 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8078 AB - Purpose: There is a need for identifying molecular prognostic biomarkers to better predict clinical outcomes in patients with renal cell carcinoma (RCC). This study investigated the pattern of cyclin D1 and p57 expression in RCC patients and evaluated their relation with clinicopathological characteristics and overall survival (OS). Methods: Immunohistochemistry was applied to paraffin-embedded tissue sections of 74 RCC patients. Two cut-off groups were defined by the fraction of positive cells as fol-lows: ≤10% and >10% positive cells for cyclin D1, and ≤5% and >5% positive cells for p57. Results: Cyclin D1 expression in >10% of positive cells was observed mostly in the clear cell RCC, while p57 expression in ≤5% of positive cells was found in 86% of chromophobe RCC specimens. The higher expression of cyclin D1 and lower expression of p57 were more frequent in grade I-II tumors. OS was associated with unfavorable clinicopathological characteristics. However, cyclin D1/p57 expression did not influence the survival rates. Conclusion: Although cyclin D1 and p57 expression did not affect survival rates in RCC patients, proper validation and establishment of the qualitative cut-off point are needed for these tumors. T2 - Journal of BUON T1 - Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma VL - 24 IS - 1 SP - 301 EP - 309 UR - https://hdl.handle.net/21.15107/rcub_vinar_8078 ER -
@article{ author = "Latić, Dragana and Pejić, Snežana and Savić, Slaviša and Lončar, Zlatibor and Nikolić, Ivan M. and Nikolić, Gorana V. and Pavlović, Ivan and Radojević-Škodrić, Sanja", year = "2019", abstract = "Purpose: There is a need for identifying molecular prognostic biomarkers to better predict clinical outcomes in patients with renal cell carcinoma (RCC). This study investigated the pattern of cyclin D1 and p57 expression in RCC patients and evaluated their relation with clinicopathological characteristics and overall survival (OS). Methods: Immunohistochemistry was applied to paraffin-embedded tissue sections of 74 RCC patients. Two cut-off groups were defined by the fraction of positive cells as fol-lows: ≤10% and >10% positive cells for cyclin D1, and ≤5% and >5% positive cells for p57. Results: Cyclin D1 expression in >10% of positive cells was observed mostly in the clear cell RCC, while p57 expression in ≤5% of positive cells was found in 86% of chromophobe RCC specimens. The higher expression of cyclin D1 and lower expression of p57 were more frequent in grade I-II tumors. OS was associated with unfavorable clinicopathological characteristics. However, cyclin D1/p57 expression did not influence the survival rates. Conclusion: Although cyclin D1 and p57 expression did not affect survival rates in RCC patients, proper validation and establishment of the qualitative cut-off point are needed for these tumors.", journal = "Journal of BUON", title = "Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma", volume = "24", number = "1", pages = "301-309", url = "https://hdl.handle.net/21.15107/rcub_vinar_8078" }
Latić, D., Pejić, S., Savić, S., Lončar, Z., Nikolić, I. M., Nikolić, G. V., Pavlović, I.,& Radojević-Škodrić, S.. (2019). Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma. in Journal of BUON, 24(1), 301-309. https://hdl.handle.net/21.15107/rcub_vinar_8078
Latić D, Pejić S, Savić S, Lončar Z, Nikolić IM, Nikolić GV, Pavlović I, Radojević-Škodrić S. Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma. in Journal of BUON. 2019;24(1):301-309. https://hdl.handle.net/21.15107/rcub_vinar_8078 .
Latić, Dragana, Pejić, Snežana, Savić, Slaviša, Lončar, Zlatibor, Nikolić, Ivan M., Nikolić, Gorana V., Pavlović, Ivan, Radojević-Škodrić, Sanja, "Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma" in Journal of BUON, 24, no. 1 (2019):301-309, https://hdl.handle.net/21.15107/rcub_vinar_8078 .