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dc.creatorStojanović, Marija
dc.creatorTodorović, Dajana D.
dc.creatorŠćepanović, Ljiljana
dc.creatorMitrović, Dušan M.
dc.creatorBorozan, Sunčica Z.
dc.creatorDragutinović, Vesna V.
dc.creatorLabudović-Borović, Milica
dc.creatorKrstić, Danijela Z.
dc.creatorČolović, Mirjana B.
dc.creatorĐurić, Dragan M.
dc.date.accessioned2019-02-27T13:50:27Z
dc.date.available2019-02-27T13:50:27Z
dc.date.issued2018
dc.identifier.issn0300-8177 (print)
dc.identifier.issn1573-4919 (electronic)
dc.identifier.urihttp://link.springer.com/10.1007/s11010-018-3311-2
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8060
dc.description.abstractThe aim of this study was to assess the effects of l-cysteine (Cys) (7 mg/kg) and N-acetyl-l-cysteine (NAC) (50 mg/kg) in the rat liver caused by subchronic i.p. application of methionine (Met) (0.8 mmol/kg) during 21 days. Malondialdehyde (MDA) concentration, glutathione content (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and acetylcholinesterase (AchE) activities were determined in the liver tissue and activities of liver enzymes (AST, ALT, ALP, and GGT) and concentrations of total proteins and albumin were determinated in plasma/serum. Catalase, superoxide dismutase, and acetylcholinesterase activities were increased by Cys and NAC. Met caused periportal mononuclear infiltration and rare focal necrosis of hepatocytes. In Cys- and NAC-supplemented groups, intracellular edema and microvesicular fatty changes without necrosis were noticed. We observed decrease of AST, ALT, and ALP activity in the methionine-treated group. Our results indicate that Cys and NAC application can increase activity of antioxidative enzymes and prevent intensive histological changes in liver in condition of subchronic methionine exposure.en
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175043/RS//
dc.rightsrestrictedAccess
dc.sourceMolecular and Cellular Biochemistry
dc.subjectMethionineen
dc.subjectAntioxidantsen
dc.subjectMorphometryen
dc.subjectBiochemical analysisen
dc.subjectLiveren
dc.subjectRaten
dc.subjectMethionineen
dc.subjectAntioxidantsen
dc.subjectMorphometryen
dc.subjectBiochemical analysisen
dc.subjectLiveren
dc.subjectRaten
dc.titleSubchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissueen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractДрагутиновић, В.; Тодоровић, Д.; Стојановић, М.; Шћепановић, Љ; Митровић, Д.; Борозан, С; Дјуриц, Д; Чоловић, М.; Крстић, Д.; Лабудовић-Боровић, М.;
dc.rights.holder© 2018, Springer Science+Business Media, LLC, part of Springer Nature
dc.citation.volume448
dc.citation.issue1-2
dc.citation.spage43
dc.citation.epage50
dc.identifier.wos000446385800005
dc.identifier.doi10.1007/s11010-018-3311-2
dc.identifier.pmid29423685
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85041517196


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