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dc.creatorOrlovska, Irina V.
dc.creatorYakovenko, I. O.
dc.creatorHaidak, Andriy H.
dc.creatorZmejkoski, Danica
dc.creatorKozyrovska, Natalia O.
dc.date.accessioned2019-02-14T09:32:30Z
dc.date.available2019-02-14T09:32:30Z
dc.date.issued2018
dc.identifier.issn0233-7657
dc.identifier.issn1993-6842
dc.identifier.urihttp://biopolymers.org.ua/doi/10.7124/bc.000979
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8029
dc.description.abstractRegenerative medicine therapy is inspired by current research advances in cellular biology, genetic engineering, synthetic biology, material sciences and so far contributes to the traditional therapy, making resistant diseases curable. Nowadays, chronic wound healing is possible due to cell-based regenerative technologies and recent non-cell therapeutic approaches. Here we review clinical applications of human stem cells, as well as cellular and tissue products as alternatives to the traditional therapy of non-healing wounds. The cell-based technologies for tissue regeneration and bioengineering utilize stem cells that are either injected into bloodstream or positioned directly into the target area. Cell-free regeneration technologies require either stem cell products, i.e., secretomes or their separate components, extracellular membrane vesicles, or tissue products. The stem cell therapies are designed to replace critically absent components of wounded or degenerative tissue. The stem cell secretome can promote the repair of damaged tissues independently of parent cells. Extracellular membrane vesicles mimic and recapitulate the mechanisms of stem cells in tissue regeneration and therefore might be promising for chronic wound and severe burns healing. The tissue products traditionally remain efficient wound healing remedies along with emerging advanced technologies. © 2018 I. V. Orlovska et al.en
dc.language.isoen
dc.rightsopenAccess
dc.sourceBiopolymers and Cell
dc.subjectwound healingen
dc.subjectcell and cell-free technologiesen
dc.subjectstem cellsen
dc.subjectsecretomesen
dc.subjectextracellular membrane vesiclesen
dc.subjecttissue producten
dc.titleRegenerative therapy for the nonhealing cutaneous woundsen
dc.typereviewen
dc.rights.licenseBY
dcterms.abstractYаковенко, И. О.; Орловска, Ирина В.; Козyровска, Наталиа О.; Змејкоски, Даница; Хаидак, Aндриy Х.;
dc.rights.holder© 2018 I. V. Orlovska et al
dc.citation.volume34
dc.citation.issue3
dc.citation.spage171
dc.citation.epage195
dc.identifier.doi10.7124/bc.000979
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85055488371
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/10983/biopolym.cell-2018-34-3-171-en.pdf


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