Regenerative therapy for the nonhealing cutaneous wounds
Authors
Orlovska, Irina V.Yakovenko, I. O.
Haidak, Andriy H.
Zmejkoski, Danica
Kozyrovska, Natalia O.
Article (Published version)
Metadata
Show full item recordAbstract
Regenerative medicine therapy is inspired by current research advances in cellular biology, genetic engineering, synthetic biology, material sciences and so far contributes to the traditional therapy, making resistant diseases curable. Nowadays, chronic wound healing is possible due to cell-based regenerative technologies and recent non-cell therapeutic approaches. Here we review clinical applications of human stem cells, as well as cellular and tissue products as alternatives to the traditional therapy of non-healing wounds. The cell-based technologies for tissue regeneration and bioengineering utilize stem cells that are either injected into bloodstream or positioned directly into the target area. Cell-free regeneration technologies require either stem cell products, i.e., secretomes or their separate components, extracellular membrane vesicles, or tissue products. The stem cell therapies are designed to replace critically absent components of wounded or degenerative tissue. The stem... cell secretome can promote the repair of damaged tissues independently of parent cells. Extracellular membrane vesicles mimic and recapitulate the mechanisms of stem cells in tissue regeneration and therefore might be promising for chronic wound and severe burns healing. The tissue products traditionally remain efficient wound healing remedies along with emerging advanced technologies. © 2018 I. V. Orlovska et al.
Keywords:
wound healing / cell and cell-free technologies / stem cells / secretomes / extracellular membrane vesicles / tissue productSource:
Biopolymers and Cell, 2018, 34, 3, 171-195URI
http://biopolymers.org.ua/doi/10.7124/bc.000979https://vinar.vin.bg.ac.rs/handle/123456789/8029
Collections
Institution/Community
VinčaTY - JOUR AU - Orlovska, Irina V. AU - Yakovenko, I. O. AU - Haidak, Andriy H. AU - Zmejkoski, Danica AU - Kozyrovska, Natalia O. PY - 2018 UR - http://biopolymers.org.ua/doi/10.7124/bc.000979 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8029 AB - Regenerative medicine therapy is inspired by current research advances in cellular biology, genetic engineering, synthetic biology, material sciences and so far contributes to the traditional therapy, making resistant diseases curable. Nowadays, chronic wound healing is possible due to cell-based regenerative technologies and recent non-cell therapeutic approaches. Here we review clinical applications of human stem cells, as well as cellular and tissue products as alternatives to the traditional therapy of non-healing wounds. The cell-based technologies for tissue regeneration and bioengineering utilize stem cells that are either injected into bloodstream or positioned directly into the target area. Cell-free regeneration technologies require either stem cell products, i.e., secretomes or their separate components, extracellular membrane vesicles, or tissue products. The stem cell therapies are designed to replace critically absent components of wounded or degenerative tissue. The stem cell secretome can promote the repair of damaged tissues independently of parent cells. Extracellular membrane vesicles mimic and recapitulate the mechanisms of stem cells in tissue regeneration and therefore might be promising for chronic wound and severe burns healing. The tissue products traditionally remain efficient wound healing remedies along with emerging advanced technologies. © 2018 I. V. Orlovska et al. T2 - Biopolymers and Cell T1 - Regenerative therapy for the nonhealing cutaneous wounds VL - 34 IS - 3 SP - 171 EP - 195 DO - 10.7124/bc.000979 ER -
@article{ author = "Orlovska, Irina V. and Yakovenko, I. O. and Haidak, Andriy H. and Zmejkoski, Danica and Kozyrovska, Natalia O.", year = "2018", abstract = "Regenerative medicine therapy is inspired by current research advances in cellular biology, genetic engineering, synthetic biology, material sciences and so far contributes to the traditional therapy, making resistant diseases curable. Nowadays, chronic wound healing is possible due to cell-based regenerative technologies and recent non-cell therapeutic approaches. Here we review clinical applications of human stem cells, as well as cellular and tissue products as alternatives to the traditional therapy of non-healing wounds. The cell-based technologies for tissue regeneration and bioengineering utilize stem cells that are either injected into bloodstream or positioned directly into the target area. Cell-free regeneration technologies require either stem cell products, i.e., secretomes or their separate components, extracellular membrane vesicles, or tissue products. The stem cell therapies are designed to replace critically absent components of wounded or degenerative tissue. The stem cell secretome can promote the repair of damaged tissues independently of parent cells. Extracellular membrane vesicles mimic and recapitulate the mechanisms of stem cells in tissue regeneration and therefore might be promising for chronic wound and severe burns healing. The tissue products traditionally remain efficient wound healing remedies along with emerging advanced technologies. © 2018 I. V. Orlovska et al.", journal = "Biopolymers and Cell", title = "Regenerative therapy for the nonhealing cutaneous wounds", volume = "34", number = "3", pages = "171-195", doi = "10.7124/bc.000979" }
Orlovska, I. V., Yakovenko, I. O., Haidak, A. H., Zmejkoski, D.,& Kozyrovska, N. O.. (2018). Regenerative therapy for the nonhealing cutaneous wounds. in Biopolymers and Cell, 34(3), 171-195. https://doi.org/10.7124/bc.000979
Orlovska IV, Yakovenko IO, Haidak AH, Zmejkoski D, Kozyrovska NO. Regenerative therapy for the nonhealing cutaneous wounds. in Biopolymers and Cell. 2018;34(3):171-195. doi:10.7124/bc.000979 .
Orlovska, Irina V., Yakovenko, I. O., Haidak, Andriy H., Zmejkoski, Danica, Kozyrovska, Natalia O., "Regenerative therapy for the nonhealing cutaneous wounds" in Biopolymers and Cell, 34, no. 3 (2018):171-195, https://doi.org/10.7124/bc.000979 . .