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The role of eNOS and iNOS in pathophysiological conditions
dc.creator | Obradović, Milan M. | |
dc.creator | Zarić, Božidarka | |
dc.creator | Sudar-Milovanović, Emina | |
dc.creator | Perović, Milan | |
dc.creator | Resanović, Ivana | |
dc.creator | Gluvić, Zoran | |
dc.creator | Isenović, Esma R. | |
dc.date.accessioned | 2019-02-01T12:55:10Z | |
dc.date.available | 2019-02-01T12:55:10Z | |
dc.date.issued | 2018 | |
dc.identifier.isbn | 9781536141856; 9781536141849 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/8014 | |
dc.description.abstract | Nitric oxide (NO) is a free radical which, in reactions with various molecules causes multiple biological effects. NO is exceptionally regulated and extends to almost every cell type and function within circulation. Generation and actions of NO are regulated by various hormones under physiological and pathophysiological conditions. Nitric oxide synthases (NOS) are the enzymes responsible for NO generation. In mammals, neuronal NOS (nNOS) and endothelial NOS (eNOS) are constitutively expressed, while inducible NOS (iNOS) mediate in immune defense. Altered NO level is associated with obesity, insulin resistance (IR), diabetes and cardiovascular diseases (CVD). Disturbances in eNOS and iNOS regulation accompany multiple changes in endothelial function and contribute to development of CVD. Furthermore, key step in initiation and progression of atherosclerosis is reduction in bioactivity of endothelial cell-derived NO. Here we shall focus on recent literature data related to the role of eNOS and iNOS in physiological and pathophysiological conditions. © 2018 Nova Science Publishers, Inc. All rights reserved. | en |
dc.language.iso | en | |
dc.publisher | Nova Science Publishers | |
dc.rights | openAccess | |
dc.source | Horizons in World Cardiovascular Research | |
dc.subject | CVD | en |
dc.subject | eNOS | en |
dc.subject | iNOS | en |
dc.subject | NO | en |
dc.title | The role of eNOS and iNOS in pathophysiological conditions | en |
dc.type | bookPart | |
dc.rights.license | ARR | |
dcterms.abstract | Исеновић, Есма Р.; Судар-Миловановић, Емина; Обрадовић, Милан М.; Перовић, Милан; Зарић, Божидарка; Глувић, Зоран; Ресановић, Ивана; | |
dc.rights.holder | © Nova Science Publishers | |
dc.citation.volume | 15 | |
dc.citation.spage | 65 | |
dc.citation.epage | 102 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85058918710 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_vinar_8014 |
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