Hypothesis related to the regulation of inducible nitric oxide synthase during carotid endarterectomy
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2019
Authors
Obradović, Milan M.Bogdanović, Nikola
Stanimirović, Julijana
Unić-Stojanović, Dragana R.
Radak, Đorđe J.
Isenović, Esma R.
Article (Published version)
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© 2018 Elsevier Ltd
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Sudden occlusion of an artery caused by a thrombus or emboli is the most frequent cause of acute brain ischemia (ABI). Carotid endarterectomy (CEA) represents the gold standard for preventing strokes of carotid origin. However, neuronal damage caused by ischemia and/or reperfusion may contribute to a poor clinical outcome after CEA. In response to shear stress caused by hypoxic-ischemic conditions in patients undergoing CEA, stimulation of the hypothalamic-pituitaryadrenal axis leads to biological responses known as hypermetabolic stress, characterized by hemodynamic, metabolic, inflammatory and immunological changes. These changes maintain homeostasis and assist recovery, but an unregulated inflammatory response could lead to further tissue damage and death of neurons. Nitric oxide (NO) is an important signaling molecule involved in several physiological and pathological processes, including ABI. However, an excess of NO could have detrimental effects. We hypothesized that the hypoxic...-ischemic state induced by carotid clamping leads to overexpression of inducible NO synthase and that uncontrolled production of NO could adversely affect outcome after CEA. © 2018 Elsevier Ltd
Keywords:
Nitric oxide / Inducible nitric oxide synthase / Carotid endarterectomySource:
Medical Hypotheses, 2019, 122, 16-18Funding / projects:
- Carotid disease in Serbia - pathologic dynamics, prevention, diagnostics and inovative therapeutic methods (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.1016/j.mehy.2018.10.011
ISSN: 0306-9877
WoS: 000457812100005
Scopus: 2-s2.0-85055124211
URI
https://linkinghub.elsevier.com/retrieve/pii/S0306987718308302https://vinar.vin.bg.ac.rs/handle/123456789/7930
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VinčaTY - JOUR AU - Obradović, Milan M. AU - Bogdanović, Nikola AU - Stanimirović, Julijana AU - Unić-Stojanović, Dragana R. AU - Radak, Đorđe J. AU - Isenović, Esma R. PY - 2019 UR - https://linkinghub.elsevier.com/retrieve/pii/S0306987718308302 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7930 AB - Sudden occlusion of an artery caused by a thrombus or emboli is the most frequent cause of acute brain ischemia (ABI). Carotid endarterectomy (CEA) represents the gold standard for preventing strokes of carotid origin. However, neuronal damage caused by ischemia and/or reperfusion may contribute to a poor clinical outcome after CEA. In response to shear stress caused by hypoxic-ischemic conditions in patients undergoing CEA, stimulation of the hypothalamic-pituitaryadrenal axis leads to biological responses known as hypermetabolic stress, characterized by hemodynamic, metabolic, inflammatory and immunological changes. These changes maintain homeostasis and assist recovery, but an unregulated inflammatory response could lead to further tissue damage and death of neurons. Nitric oxide (NO) is an important signaling molecule involved in several physiological and pathological processes, including ABI. However, an excess of NO could have detrimental effects. We hypothesized that the hypoxic-ischemic state induced by carotid clamping leads to overexpression of inducible NO synthase and that uncontrolled production of NO could adversely affect outcome after CEA. © 2018 Elsevier Ltd T2 - Medical Hypotheses T1 - Hypothesis related to the regulation of inducible nitric oxide synthase during carotid endarterectomy VL - 122 SP - 16 EP - 18 DO - 10.1016/j.mehy.2018.10.011 ER -
@article{ author = "Obradović, Milan M. and Bogdanović, Nikola and Stanimirović, Julijana and Unić-Stojanović, Dragana R. and Radak, Đorđe J. and Isenović, Esma R.", year = "2019", abstract = "Sudden occlusion of an artery caused by a thrombus or emboli is the most frequent cause of acute brain ischemia (ABI). Carotid endarterectomy (CEA) represents the gold standard for preventing strokes of carotid origin. However, neuronal damage caused by ischemia and/or reperfusion may contribute to a poor clinical outcome after CEA. In response to shear stress caused by hypoxic-ischemic conditions in patients undergoing CEA, stimulation of the hypothalamic-pituitaryadrenal axis leads to biological responses known as hypermetabolic stress, characterized by hemodynamic, metabolic, inflammatory and immunological changes. These changes maintain homeostasis and assist recovery, but an unregulated inflammatory response could lead to further tissue damage and death of neurons. Nitric oxide (NO) is an important signaling molecule involved in several physiological and pathological processes, including ABI. However, an excess of NO could have detrimental effects. We hypothesized that the hypoxic-ischemic state induced by carotid clamping leads to overexpression of inducible NO synthase and that uncontrolled production of NO could adversely affect outcome after CEA. © 2018 Elsevier Ltd", journal = "Medical Hypotheses", title = "Hypothesis related to the regulation of inducible nitric oxide synthase during carotid endarterectomy", volume = "122", pages = "16-18", doi = "10.1016/j.mehy.2018.10.011" }
Obradović, M. M., Bogdanović, N., Stanimirović, J., Unić-Stojanović, D. R., Radak, Đ. J.,& Isenović, E. R.. (2019). Hypothesis related to the regulation of inducible nitric oxide synthase during carotid endarterectomy. in Medical Hypotheses, 122, 16-18. https://doi.org/10.1016/j.mehy.2018.10.011
Obradović MM, Bogdanović N, Stanimirović J, Unić-Stojanović DR, Radak ĐJ, Isenović ER. Hypothesis related to the regulation of inducible nitric oxide synthase during carotid endarterectomy. in Medical Hypotheses. 2019;122:16-18. doi:10.1016/j.mehy.2018.10.011 .
Obradović, Milan M., Bogdanović, Nikola, Stanimirović, Julijana, Unić-Stojanović, Dragana R., Radak, Đorđe J., Isenović, Esma R., "Hypothesis related to the regulation of inducible nitric oxide synthase during carotid endarterectomy" in Medical Hypotheses, 122 (2019):16-18, https://doi.org/10.1016/j.mehy.2018.10.011 . .