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dc.creatorŽeljić, Katarina
dc.creatorJovanović, Ivan G.
dc.creatorJovanović, Jasmina
dc.creatorMagić, Zvonko
dc.creatorStanković, Aleksandra
dc.creatorŠupić, Gordana
dc.date.accessioned2018-06-09T10:41:37Z
dc.date.accessioned2018-10-08T09:05:22Z
dc.date.available2018-06-09T10:41:37Z
dc.date.available2018-10-08T09:05:22Z
dc.date.issued2018
dc.identifier.issn0300-9734 (print)
dc.identifier.issn2000-1967 (electronic)
dc.identifier.urihttps://figshare.com/articles/MicroRNA_meta-signature_of_oral_cancer_evidence_from_a_meta-analysis/5926675
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7843
dc.description.abstractAim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS//
dc.relationFaculty of Medicine, Military Medical Academy, Belgrade, Serbia [MFVMA/11/16-18]
dc.rightsopenAccess
dc.sourceUpsala Journal of Medical Sciences
dc.subjectenrichment analysisen
dc.subjectmeta-analysisen
dc.subjectmeta-signatureen
dc.subjectmiRNAen
dc.subjectoral canceren
dc.titleMicroRNA meta-signature of oral cancer: evidence from a meta-analysis
dc.typeotheren
dc.rights.licenseBY
dcterms.abstractЈовановић, Иван Г.; Шупић, Гордана; Жељић, Катарина; Станковић, Aлександра; Јовановић, Јасмина; Магић, Звонко;
dc.citation.volume123
dc.citation.issue1
dc.citation.spage43
dc.citation.epage49
dc.identifier.wos000428060300005
dc.identifier.doi10.6084/m9.figshare.5926675
dc.identifier.pmid29482431
dc.description.otherSupplementary data for the article:[https://doi.org/10.1080/03009734.2018.1439551]
dc.description.otherRelated to: [http://vinar.vin.bg.ac.rs/123456789/7630]
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85042931110


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