Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation
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2018
Authors
Bogdanović, UnaDimitrijević, Suzana I.
Škapin, Srečo Davor
Popović, Maja
Rakočević, Zlatko Lj.
Leskovac, Andreja
Petrović, Sandra
Stoiljković, Milovan
Vodnik, Vesna
Article (Published version)
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© 2018 Elsevier B.V.
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Copper nanoparticles (Cu NPs) have proven to own excellent antimicrobial efficacy, but the problems of easy oxidation and aggregation limit their practical application. Here, nanocomposite based on polyaniline (PANI) and Cu NPs solved this problem and brought additional physicochemical properties that are markedly advantageous for antimicrobial applications. Current work exploits this potential, to examine its time- and concentration-dependent antimicrobial activity, employing E. coli, S. aureus, and C. albicans as a model microbial species. Regarding the presence of polaronic charge carriers in the fibrous polyaniline network, effects of Cu NPs’ size and their partially oxidized surfaces (the data were confirmed by HRTEM, FESEM, XRD, Raman and XPS analysis), as well as rapid copper ions release, Cu-PANI nanocomposite showed efficient bactericidal and fungicidal activities at the concentrations ≤1 ppm, within the incubation time of 2 h. Beside the quantitative analysis, the high levels... of cellular disruption for all tested microbes were evidenced by atomic force microscopy. Moreover, the minimum inhibitory and bactericidal concentrations of the Cu-PANI nanocomposite were lower than those reported for other nanocomposites. Using such low concentrations is recognized as a good way to avoid its toxicity toward the environment. For this purpose, Cu-PANI nanocomposite is tested for its genotoxicity and influence on the oxidative status of the human cells in vitro.
Keywords:
copper nanoparticles / polyaniline / nanocomposite / antimicrobial activity / genotoxicity / oxidative statusSource:
Materials Science and Engineering: C, 2018, 93, 49-60Funding / projects:
- Size-, shape- and structure- dependent properties of nanoparticles and nanocomposites (RS-MESTD-Basic Research (BR or ON)-172056)
- Application of biotechnological methods for sustainable exploitation of by-products of agro-industry (RS-MESTD-Technological Development (TD or TR)-31035)
DOI: 10.1016/j.msec.2018.07.067
ISSN: 0928-4931; 1873-0191
PubMed: 30274082
WoS: 000447569400006
Scopus: 2-s2.0-85050384883
URI
https://linkinghub.elsevier.com/retrieve/pii/S0928493117326449https://vinar.vin.bg.ac.rs/handle/123456789/7799
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VinčaTY - JOUR AU - Bogdanović, Una AU - Dimitrijević, Suzana I. AU - Škapin, Srečo Davor AU - Popović, Maja AU - Rakočević, Zlatko Lj. AU - Leskovac, Andreja AU - Petrović, Sandra AU - Stoiljković, Milovan AU - Vodnik, Vesna PY - 2018 UR - https://linkinghub.elsevier.com/retrieve/pii/S0928493117326449 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7799 AB - Copper nanoparticles (Cu NPs) have proven to own excellent antimicrobial efficacy, but the problems of easy oxidation and aggregation limit their practical application. Here, nanocomposite based on polyaniline (PANI) and Cu NPs solved this problem and brought additional physicochemical properties that are markedly advantageous for antimicrobial applications. Current work exploits this potential, to examine its time- and concentration-dependent antimicrobial activity, employing E. coli, S. aureus, and C. albicans as a model microbial species. Regarding the presence of polaronic charge carriers in the fibrous polyaniline network, effects of Cu NPs’ size and their partially oxidized surfaces (the data were confirmed by HRTEM, FESEM, XRD, Raman and XPS analysis), as well as rapid copper ions release, Cu-PANI nanocomposite showed efficient bactericidal and fungicidal activities at the concentrations ≤1 ppm, within the incubation time of 2 h. Beside the quantitative analysis, the high levels of cellular disruption for all tested microbes were evidenced by atomic force microscopy. Moreover, the minimum inhibitory and bactericidal concentrations of the Cu-PANI nanocomposite were lower than those reported for other nanocomposites. Using such low concentrations is recognized as a good way to avoid its toxicity toward the environment. For this purpose, Cu-PANI nanocomposite is tested for its genotoxicity and influence on the oxidative status of the human cells in vitro. T2 - Materials Science and Engineering: C T1 - Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation VL - 93 SP - 49 EP - 60 DO - 10.1016/j.msec.2018.07.067 ER -
@article{ author = "Bogdanović, Una and Dimitrijević, Suzana I. and Škapin, Srečo Davor and Popović, Maja and Rakočević, Zlatko Lj. and Leskovac, Andreja and Petrović, Sandra and Stoiljković, Milovan and Vodnik, Vesna", year = "2018", abstract = "Copper nanoparticles (Cu NPs) have proven to own excellent antimicrobial efficacy, but the problems of easy oxidation and aggregation limit their practical application. Here, nanocomposite based on polyaniline (PANI) and Cu NPs solved this problem and brought additional physicochemical properties that are markedly advantageous for antimicrobial applications. Current work exploits this potential, to examine its time- and concentration-dependent antimicrobial activity, employing E. coli, S. aureus, and C. albicans as a model microbial species. Regarding the presence of polaronic charge carriers in the fibrous polyaniline network, effects of Cu NPs’ size and their partially oxidized surfaces (the data were confirmed by HRTEM, FESEM, XRD, Raman and XPS analysis), as well as rapid copper ions release, Cu-PANI nanocomposite showed efficient bactericidal and fungicidal activities at the concentrations ≤1 ppm, within the incubation time of 2 h. Beside the quantitative analysis, the high levels of cellular disruption for all tested microbes were evidenced by atomic force microscopy. Moreover, the minimum inhibitory and bactericidal concentrations of the Cu-PANI nanocomposite were lower than those reported for other nanocomposites. Using such low concentrations is recognized as a good way to avoid its toxicity toward the environment. For this purpose, Cu-PANI nanocomposite is tested for its genotoxicity and influence on the oxidative status of the human cells in vitro.", journal = "Materials Science and Engineering: C", title = "Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation", volume = "93", pages = "49-60", doi = "10.1016/j.msec.2018.07.067" }
Bogdanović, U., Dimitrijević, S. I., Škapin, S. D., Popović, M., Rakočević, Z. Lj., Leskovac, A., Petrović, S., Stoiljković, M.,& Vodnik, V.. (2018). Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation. in Materials Science and Engineering: C, 93, 49-60. https://doi.org/10.1016/j.msec.2018.07.067
Bogdanović U, Dimitrijević SI, Škapin SD, Popović M, Rakočević ZL, Leskovac A, Petrović S, Stoiljković M, Vodnik V. Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation. in Materials Science and Engineering: C. 2018;93:49-60. doi:10.1016/j.msec.2018.07.067 .
Bogdanović, Una, Dimitrijević, Suzana I., Škapin, Srečo Davor, Popović, Maja, Rakočević, Zlatko Lj., Leskovac, Andreja, Petrović, Sandra, Stoiljković, Milovan, Vodnik, Vesna, "Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation" in Materials Science and Engineering: C, 93 (2018):49-60, https://doi.org/10.1016/j.msec.2018.07.067 . .