Acute toxicity study in mice of orally administrated TiO 2 nanoparticles functionalized with caffeic acid
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2018
Authors
Dekanski, DraganaSpremo-Potparević, Biljana
Bajić, Vladan P.
Živković, Lada
Topalović, Dijana
Sredojević, Dušan
Lazić, Vesna M.
Nedeljković, Jovan
Article (Published version)
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© 2018 Elsevier Ltd
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The acute toxicity of surface-modified TiO2 nanoparticles (NPs) with caffeic acid (CA) was compared with those of its separate constituents (free CA and bare TiO2 NPs) upon their oral administration in laboratory mice. Prior to in vivo experiments, the interfacial charge transfer (ICT) complex between surface Ti atoms and CA is thoroughly characterized. Composition and stability constants of ICT complex were determined using Job's method and Banesi-Hildebrand analysis, respectively. The experimental data were supported with quantum chemical calculations based on density functional theory (DFT). Acute toxicity signs, including biochemical alterations and extensive histopathological changes in the liver tissue of mice were detected 14 days after oral administration of bare TiO2 NPs. However, the clinical signs of toxicity, the fractional contribution of organs, biochemical parameters of liver and kidney function, and histopathological changes in liver upon treatment with surface-modified... TiO2 NPs with CA were not observed. Also, the genotoxic potential of the ICT complex and its constituents were evaluated in leukocytes of whole blood cells in vivo by comet assay. Both, bare and surface-modified TiO2 NPs did not display DNA damaging effect in time frame of 24 h upon their oral administration in mice.
Keywords:
acute oral toxicity / caffeic acid / comet assay / interfacial charge transfer complex / TiO2 nanoparticlesSource:
Food and Chemical Toxicology, 2018, 115, 42-48Funding / projects:
- Materials of Reduced Dimensions for Efficient Light Harvesting and Energy conversion (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45020)
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-MESTD-Basic Research (BR or ON)-173034)
DOI: 10.1016/j.fct.2018.02.064
ISSN: 0278-6915; 1873-6351
PubMed: 29510221
WoS: 000432644400006
Scopus: 2-s2.0-85042915198
URI
https://linkinghub.elsevier.com/retrieve/pii/S0278691518301388https://vinar.vin.bg.ac.rs/handle/123456789/7790
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VinčaTY - JOUR AU - Dekanski, Dragana AU - Spremo-Potparević, Biljana AU - Bajić, Vladan P. AU - Živković, Lada AU - Topalović, Dijana AU - Sredojević, Dušan AU - Lazić, Vesna M. AU - Nedeljković, Jovan PY - 2018 UR - https://linkinghub.elsevier.com/retrieve/pii/S0278691518301388 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7790 AB - The acute toxicity of surface-modified TiO2 nanoparticles (NPs) with caffeic acid (CA) was compared with those of its separate constituents (free CA and bare TiO2 NPs) upon their oral administration in laboratory mice. Prior to in vivo experiments, the interfacial charge transfer (ICT) complex between surface Ti atoms and CA is thoroughly characterized. Composition and stability constants of ICT complex were determined using Job's method and Banesi-Hildebrand analysis, respectively. The experimental data were supported with quantum chemical calculations based on density functional theory (DFT). Acute toxicity signs, including biochemical alterations and extensive histopathological changes in the liver tissue of mice were detected 14 days after oral administration of bare TiO2 NPs. However, the clinical signs of toxicity, the fractional contribution of organs, biochemical parameters of liver and kidney function, and histopathological changes in liver upon treatment with surface-modified TiO2 NPs with CA were not observed. Also, the genotoxic potential of the ICT complex and its constituents were evaluated in leukocytes of whole blood cells in vivo by comet assay. Both, bare and surface-modified TiO2 NPs did not display DNA damaging effect in time frame of 24 h upon their oral administration in mice. T2 - Food and Chemical Toxicology T1 - Acute toxicity study in mice of orally administrated TiO 2 nanoparticles functionalized with caffeic acid VL - 115 SP - 42 EP - 48 DO - 10.1016/j.fct.2018.02.064 ER -
@article{ author = "Dekanski, Dragana and Spremo-Potparević, Biljana and Bajić, Vladan P. and Živković, Lada and Topalović, Dijana and Sredojević, Dušan and Lazić, Vesna M. and Nedeljković, Jovan", year = "2018", abstract = "The acute toxicity of surface-modified TiO2 nanoparticles (NPs) with caffeic acid (CA) was compared with those of its separate constituents (free CA and bare TiO2 NPs) upon their oral administration in laboratory mice. Prior to in vivo experiments, the interfacial charge transfer (ICT) complex between surface Ti atoms and CA is thoroughly characterized. Composition and stability constants of ICT complex were determined using Job's method and Banesi-Hildebrand analysis, respectively. The experimental data were supported with quantum chemical calculations based on density functional theory (DFT). Acute toxicity signs, including biochemical alterations and extensive histopathological changes in the liver tissue of mice were detected 14 days after oral administration of bare TiO2 NPs. However, the clinical signs of toxicity, the fractional contribution of organs, biochemical parameters of liver and kidney function, and histopathological changes in liver upon treatment with surface-modified TiO2 NPs with CA were not observed. Also, the genotoxic potential of the ICT complex and its constituents were evaluated in leukocytes of whole blood cells in vivo by comet assay. Both, bare and surface-modified TiO2 NPs did not display DNA damaging effect in time frame of 24 h upon their oral administration in mice.", journal = "Food and Chemical Toxicology", title = "Acute toxicity study in mice of orally administrated TiO 2 nanoparticles functionalized with caffeic acid", volume = "115", pages = "42-48", doi = "10.1016/j.fct.2018.02.064" }
Dekanski, D., Spremo-Potparević, B., Bajić, V. P., Živković, L., Topalović, D., Sredojević, D., Lazić, V. M.,& Nedeljković, J.. (2018). Acute toxicity study in mice of orally administrated TiO 2 nanoparticles functionalized with caffeic acid. in Food and Chemical Toxicology, 115, 42-48. https://doi.org/10.1016/j.fct.2018.02.064
Dekanski D, Spremo-Potparević B, Bajić VP, Živković L, Topalović D, Sredojević D, Lazić VM, Nedeljković J. Acute toxicity study in mice of orally administrated TiO 2 nanoparticles functionalized with caffeic acid. in Food and Chemical Toxicology. 2018;115:42-48. doi:10.1016/j.fct.2018.02.064 .
Dekanski, Dragana, Spremo-Potparević, Biljana, Bajić, Vladan P., Živković, Lada, Topalović, Dijana, Sredojević, Dušan, Lazić, Vesna M., Nedeljković, Jovan, "Acute toxicity study in mice of orally administrated TiO 2 nanoparticles functionalized with caffeic acid" in Food and Chemical Toxicology, 115 (2018):42-48, https://doi.org/10.1016/j.fct.2018.02.064 . .