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dc.creatorKornjača, Duško
dc.creatorŽivković, Vladimir I.
dc.creatorKrstić, Danijela Z.
dc.creatorČolović, Mirjana B.
dc.creatorĐurić, Marko
dc.creatorStanković, Sanja
dc.creatorMutavdžin, Slavica
dc.creatorJakovljević, Vladimir Lj.
dc.creatorĐurić, Dragan M.
dc.date.accessioned2018-07-05T12:27:35Z
dc.date.available2018-07-05T12:27:35Z
dc.date.issued2018
dc.identifier.issn0354-4664
dc.identifier.issn1821-4339
dc.identifier.urihttp://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641700041K
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/7714
dc.description.abstractThe aim of this study was to assess the effects of DL-homocysteine (DL-Hcy) and DL-homocysteine thiolactone (DL-Hcy TLHC) on selected serum biochemical parameters, markers of oxidative stress and the activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the plasma, as well as on acetylcholinesterase (AChE) activity in the cardiac tissue homogenate in the rat. Male Wistar rats were divided into three groups as follows: control group (1 mL 0.9% NaCl, intraperitoneal (i.p.) injection), DL-Hcy group (8 mmol/kg body mass (b.m.), i.p.) or DL-Hcy TLHC group (8 mmol/kg b.m., i.p.). One hour after administration, the rats were euthanized, whole blood was collected for biochemical analysis, and the heart was excised. Following the i.p. administration of DL-Hcy and DL-Hcy TLHC, the activities of antioxidant enzymes were mostly significantly increased, while plasma malondialdehyde (MDA) was decreased. Administration of DL-Hcy and DL-Hcy TLHC significantly inhibited AChE activity in rat cardiac tissue. Our findings suggest that DL-Hcy and DL-Hcy TLHC exerted prooxidant effects; however, the decrease in MDA points to an inverse response to the increase in antioxidant enzyme activities. While both substances inhibited AChE activity in rat cardiac tissue, DL-Hcy TLHC induced stronger effects than DL-Hcy.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175043/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArchives of Biological Sciences
dc.subjectacetylcholinesteraseen
dc.subjectantioxidant enzymesen
dc.subjectDL-homocysteineen
dc.subjectDL-homocysteine thiolactoneen
dc.subjectraten
dc.titleThe effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the raten
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractДјуриц, Марко; Зивковиц, Владимир; Станковиц, Сања; Дјуриц, Драган; Корњаца, Дуско; Крстиц, Данијела; Цоловиц, Мирјана; Мутавдзин, Славица; Јаковљевиц, Владимир;
dc.rights.holder© 2018 by the Serbian Biological Society
dc.citation.volume70
dc.citation.issue2
dc.citation.spage241
dc.citation.epage248
dc.identifier.wos000434006700003
dc.identifier.doi10.2298/ABS170731041K
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85047895570
dc.identifier.fulltexthttps://vinar.vin.bg.ac.rs//bitstream/id/10154/0354-46641700041K.pdf


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