Light controllable TiO2-Ru nanocomposite system encapsulated in phospholipid unilamellar vesicles for anti-cancer photodynamic therapy

Matijević, Milica; Nešić, Maja A.; Stepić, Milutin; Radoičić, Marija B.; Šaponjić, Zoran; Petković, Marijana

doi:10.1007/s11082-018-1495-z

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Matijević, Milica

Nešić, Maja A.
Stepić, Milutin

Radoičić, Marija B.

Šaponjić, Zoran

Petković, Marijana

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Abstract

Photodynamic therapy implies a combined use of a photosensitizing medicament and low-intensity light to cause selective damage to the target tissue—tumor. As potential medicament, we use Ru(II)(dcbpy)2Cl2complex, and in order to achieve better photosensitization properties, the Ru complex was attached to the nano carrier—TiO2nanoparticles. Additionally, this nanocomposite system was encapsulated in the phospholipid vesicles, which could be classified as small unilamellar vesicles, based on the technique of production. The complex-release tests were performed under light illumination, at pH 5, characteristic for tumor cells` interior and compared with the release pattern at pH 7, characteristic for the serum, i.e. physiological solution.

Keywords:

photodynamic therapy / light controlled drug release / metallo-drug delivery

Source:
Optical and Quantum Electronics, 2018, 50, 6, 232-

Funding / projects:

DOI: 10.1007/s11082-018-1495-z

ISSN: 0306-8919; 1572-817X

WoS: 000433079400001

Scopus: 2-s2.0-85047448688

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	1

TY  - JOUR
AU  - Matijević, Milica
AU  - Nešić, Maja A.
AU  - Stepić, Milutin
AU  - Radoičić, Marija B.
AU  - Šaponjić, Zoran
AU  - Petković, Marijana
PY  - 2018
UR  - http://link.springer.com/10.1007/s11082-018-1495-z
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7697
AB  - Photodynamic therapy implies a combined use of a photosensitizing medicament and low-intensity light to cause selective damage to the target tissue—tumor. As potential medicament, we use Ru(II)(dcbpy)2Cl2complex, and in order to achieve better photosensitization properties, the Ru complex was attached to the nano carrier—TiO2nanoparticles. Additionally, this nanocomposite system was encapsulated in the phospholipid vesicles, which could be classified as small unilamellar vesicles, based on the technique of production. The complex-release tests were performed under light illumination, at pH 5, characteristic for tumor cells` interior and compared with the release pattern at pH 7, characteristic for the serum, i.e. physiological solution.
T2  - Optical and Quantum Electronics
T1  - Light controllable TiO2-Ru nanocomposite system encapsulated in phospholipid unilamellar vesicles for anti-cancer photodynamic therapy
VL  - 50
IS  - 6
SP  - 232
DO  - 10.1007/s11082-018-1495-z
ER  -

@article{
author = "Matijević, Milica and Nešić, Maja A. and Stepić, Milutin and Radoičić, Marija B. and Šaponjić, Zoran and Petković, Marijana",
year = "2018",
abstract = "Photodynamic therapy implies a combined use of a photosensitizing medicament and low-intensity light to cause selective damage to the target tissue—tumor. As potential medicament, we use Ru(II)(dcbpy)2Cl2complex, and in order to achieve better photosensitization properties, the Ru complex was attached to the nano carrier—TiO2nanoparticles. Additionally, this nanocomposite system was encapsulated in the phospholipid vesicles, which could be classified as small unilamellar vesicles, based on the technique of production. The complex-release tests were performed under light illumination, at pH 5, characteristic for tumor cells` interior and compared with the release pattern at pH 7, characteristic for the serum, i.e. physiological solution.",
journal = "Optical and Quantum Electronics",
title = "Light controllable TiO2-Ru nanocomposite system encapsulated in phospholipid unilamellar vesicles for anti-cancer photodynamic therapy",
volume = "50",
number = "6",
pages = "232",
doi = "10.1007/s11082-018-1495-z"
}

Matijević, M., Nešić, M. A., Stepić, M., Radoičić, M. B., Šaponjić, Z.,& Petković, M.. (2018). Light controllable TiO2-Ru nanocomposite system encapsulated in phospholipid unilamellar vesicles for anti-cancer photodynamic therapy. in Optical and Quantum Electronics, 50(6), 232.
https://doi.org/10.1007/s11082-018-1495-z

Matijević M, Nešić MA, Stepić M, Radoičić MB, Šaponjić Z, Petković M. Light controllable TiO2-Ru nanocomposite system encapsulated in phospholipid unilamellar vesicles for anti-cancer photodynamic therapy. in Optical and Quantum Electronics. 2018;50(6):232.
doi:10.1007/s11082-018-1495-z .

Matijević, Milica, Nešić, Maja A., Stepić, Milutin, Radoičić, Marija B., Šaponjić, Zoran, Petković, Marijana, "Light controllable TiO2-Ru nanocomposite system encapsulated in phospholipid unilamellar vesicles for anti-cancer photodynamic therapy" in Optical and Quantum Electronics, 50, no. 6 (2018):232,
https://doi.org/10.1007/s11082-018-1495-z . .