The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.
TY - JOUR
AU - Paessler, Slobodan
AU - Huang, Cheng
AU - Senćanski, Milan V.
AU - Veljković, Nevena V.
AU - Perović, Vladimir R.
AU - Glišić, Sanja
AU - Veljković, Veljko
PY - 2018
UR - https://vinar.vin.bg.ac.rs/handle/123456789/7695
AB - The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.
T2 - Frontiers in Bioscience - Landmark
T1 - Ibuprofen as a template molecule for drug design against Ebola virus
VL - 23
IS - 5
SP - 947
EP - 953
UR - https://hdl.handle.net/21.15107/rcub_vinar_7695
ER -
@article{
author = "Paessler, Slobodan and Huang, Cheng and Senćanski, Milan V. and Veljković, Nevena V. and Perović, Vladimir R. and Glišić, Sanja and Veljković, Veljko",
year = "2018",
abstract = "The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.",
journal = "Frontiers in Bioscience - Landmark",
title = "Ibuprofen as a template molecule for drug design against Ebola virus",
volume = "23",
number = "5",
pages = "947-953",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7695"
}
Paessler, S., Huang, C., Senćanski, M. V., Veljković, N. V., Perović, V. R., Glišić, S.,& Veljković, V.. (2018). Ibuprofen as a template molecule for drug design against Ebola virus. in Frontiers in Bioscience - Landmark, 23(5), 947-953.
https://hdl.handle.net/21.15107/rcub_vinar_7695
Paessler S, Huang C, Senćanski MV, Veljković NV, Perović VR, Glišić S, Veljković V. Ibuprofen as a template molecule for drug design against Ebola virus. in Frontiers in Bioscience - Landmark. 2018;23(5):947-953.
https://hdl.handle.net/21.15107/rcub_vinar_7695 .
Paessler, Slobodan, Huang, Cheng, Senćanski, Milan V., Veljković, Nevena V., Perović, Vladimir R., Glišić, Sanja, Veljković, Veljko, "Ibuprofen as a template molecule for drug design against Ebola virus" in Frontiers in Bioscience - Landmark, 23, no. 5 (2018):947-953,
https://hdl.handle.net/21.15107/rcub_vinar_7695 .
, 