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The Allele 2 of the VNTR Polymorphism in the Gene That Encodes a Natural Inhibitor of IL-1β, IL-1RA Is Favorably Associated With Chronic Otitis Media

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Zivkovic_2017_The_allele_2_of_the_VNTR.pdf (380.5Kb)
Authors
Živković, Maja
Kolić, Ivana
Ješić, Snežana
Jotić, Ana
Stanković, Aleksandra
Article (Published version)
,
© 2018 by Korean Society of Otorhinolaryngology-Head and Neck Surgery
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Abstract
Objectives. Chronic otitis media (COM) is followed by irreversible tissue damage and destruction of the middle ear structures, with the possibility of complications under the maintenance of inflammation. Inflammatory mediators such as cytokines play a crucial role in the initial stage of inflammation. The aim of this study was to evaluate the association of the polymorphisms in two innate immunity/inflammation cascade genes from interleukin-1 (IL-1) gene cluster with COM with regard to cholesteatoma. Methods. In the cross-sectional case-control study, DNA samples were collected from 189 patients with COM and 119 controls from a population of Serbia. The +3953 C/T (rs1143634), TaqI polymorphism in interleukin-1 beta (IL-1Β) gene and 86 bp variable number tandem repeat (VNTR, rs2234663) polymorphism in the IL-1 receptor antagonist (IL-1RA) gene were analyzed by polymerase chain reaction. Results. The IL-1Β TaqI polymorphism was not significantly different in patients compared with the co...ntrol group. The significant difference between patients and controls was observed for both, genotype and allele frequencies of IL-1RA VNTR polymorphism (chi-square P<0.01). We found that carriers of IL-1RA allele 2 (odds ratio, 0.47; 95% confidence interval, 0.29 to 0.76; P=0.004) have a favorable association with COM, using multivariate logistic analysis that included both polymorphisms, age and sex. The IL-1RA allele frequency distribution was significantly different with regard to cholesteatoma. Conclusion. The carriers of allele 2 of VNTR IL-1RA polymorphism had a decreased odds ratio for COM, which is in agreement with findings in other inflammatory disease and its previous association with higher IL-1RA levels. Possible down-regulation of IL-1 mediated proinflammatory signaling pathways via IL-1RA in COM as well as results of our study should be further investigated and replicated.

Keywords:
cholesteatoma / genetic polymorphism / interleukin-1 receptor antagonist / interleukin-1Beta / otitis media
Source:
Clinical and Experimental Otorhinolaryngology, 2018, 11, 2, 118-123
Projects:
  • Genetic basis of human vascular and inflammatory diseases (RS-175085)

DOI: 10.21053/ceo.2017.01060

ISSN: 1976-8710 (print); 2005-0720 (electronic)

PubMed: 29433161

WoS: 000433270700007

Scopus: 2-s2.0-85046099306
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URI
http://e-ceo.org/journal/view.php?doi=10.21053/ceo.2017.01060
http://vinar.vin.bg.ac.rs/handle/123456789/7677
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