Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche)
Autori
Vasić, NovakGlumac, Sofija
Pejić, Snežana
Amidžić, L. J.
Tadić-Latinović, Ljiljana J.
Dožić, Branko S.
Hinić, Saša
Maksimović, Živan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
© 2017 Charles University. All rights reserved. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and m...acrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation.
Ključne reči:
abdominal aortic aneurysm / aortoiliac occlusive disease / matrix metalloproteinases / syndrome LericheIzvor:
Folia Biologica (Czech Republic), 2017, 63, 5-6, 209-216Finansiranje / projekti:
- Ministry of Science and Technology of the Republic of Srpska
Institucija/grupa
VinčaTY - JOUR AU - Vasić, Novak AU - Glumac, Sofija AU - Pejić, Snežana AU - Amidžić, L. J. AU - Tadić-Latinović, Ljiljana J. AU - Dožić, Branko S. AU - Hinić, Saša AU - Maksimović, Živan PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7676 AB - © 2017 Charles University. All rights reserved. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation. T2 - Folia Biologica (Czech Republic) T1 - Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche) VL - 63 IS - 5-6 SP - 209 EP - 216 UR - https://hdl.handle.net/21.15107/rcub_vinar_7676 ER -
@article{ author = "Vasić, Novak and Glumac, Sofija and Pejić, Snežana and Amidžić, L. J. and Tadić-Latinović, Ljiljana J. and Dožić, Branko S. and Hinić, Saša and Maksimović, Živan", year = "2017", abstract = "© 2017 Charles University. All rights reserved. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation.", journal = "Folia Biologica (Czech Republic)", title = "Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche)", volume = "63", number = "5-6", pages = "209-216", url = "https://hdl.handle.net/21.15107/rcub_vinar_7676" }
Vasić, N., Glumac, S., Pejić, S., Amidžić, L. J., Tadić-Latinović, L. J., Dožić, B. S., Hinić, S.,& Maksimović, Ž.. (2017). Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche). in Folia Biologica (Czech Republic), 63(5-6), 209-216. https://hdl.handle.net/21.15107/rcub_vinar_7676
Vasić N, Glumac S, Pejić S, Amidžić LJ, Tadić-Latinović LJ, Dožić BS, Hinić S, Maksimović Ž. Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche). in Folia Biologica (Czech Republic). 2017;63(5-6):209-216. https://hdl.handle.net/21.15107/rcub_vinar_7676 .
Vasić, Novak, Glumac, Sofija, Pejić, Snežana, Amidžić, L. J., Tadić-Latinović, Ljiljana J., Dožić, Branko S., Hinić, Saša, Maksimović, Živan, "Expression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche)" in Folia Biologica (Czech Republic), 63, no. 5-6 (2017):209-216, https://hdl.handle.net/21.15107/rcub_vinar_7676 .