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MicroRNA meta-signature of oral cancer: evidence from a meta-analysis
dc.creator | Željić, Katarina | |
dc.creator | Jovanović, Ivan G. | |
dc.creator | Jovanović, Jasmina | |
dc.creator | Magić, Zvonko | |
dc.creator | Stanković, Aleksandra | |
dc.creator | Šupić, Gordana | |
dc.date.accessioned | 2018-06-09T10:41:37Z | |
dc.date.available | 2018-06-09T10:41:37Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0300-9734 | |
dc.identifier.issn | 2000-1967 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/03009734.2018.1439551 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/7630 | |
dc.description.abstract | Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS// | |
dc.relation | Faculty of Medicine, Military Medical Academy, Belgrade, Serbia [MFVMA/11/16-18] | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Upsala Journal of Medical Sciences | |
dc.subject | enrichment analysis | en |
dc.subject | meta-analysis | en |
dc.subject | meta-signature | en |
dc.subject | miRNA | en |
dc.subject | oral cancer | en |
dc.title | MicroRNA meta-signature of oral cancer: evidence from a meta-analysis | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Станковић, Aлександра; Јовановиц, Јасмина; Магиц, Звонко; Зељиц, Катарина; Јовановић, Иван Г.; Супиц, Гордана; | |
dc.citation.volume | 123 | |
dc.citation.issue | 1 | |
dc.citation.spage | 43 | |
dc.citation.epage | 49 | |
dc.identifier.wos | 000428060300005 | |
dc.identifier.doi | 10.1080/03009734.2018.1439551 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 29482431 | |
dc.description.other | Supplemental data at [https://doi.org/10.6084/m9.figshare.5926675] | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85042931110 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/9964/MicroRNA_meta_signature_of_oral_cancer.pdf |
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