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Homocysteine and Hyperhomocysteinaemia
(Current Medicinal Chemistry, 2019)
Homocysteine (Hcy) is a thiol group containing the amino acid, which naturally occurs in all humans. Hcy is degraded in the body through two metabolic pathways, while a minor part is excreted through kidneys. The chemical ...
Recent In Silico Resources for Drug Design and Discovery (Editorial)
(Current Medicinal Chemistry, 2019)
Tryptophan Metabolism in Atherosclerosis and Diabetes
(Current Medicinal Chemistry, 2022)
The essential amino acid tryptophan (Trp) undergoes catabolism through several pathways, producing biologically active metabolites that significantly impact physiological processes. The metabolic pathway responsible for ...
The Link between miRNAs and PCKS9 in Atherosclerosis
(Current Medicinal Chemistry, 2023)
Cardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing ...
The Role of miRNAs in Metabolic Diseases
(Current Medicinal Chemistry, 2023)
Metabolic diseases such as obesity, diabetes, dyslipidemia, and insulin resistance are characterized by glucose and lipid metabolism alterations and represent a global health problem. Many studies have established the ...
Endothelial dysfunction in dyslipidaemia: Molecular mechanisms and clinical implications
(Current Medicinal Chemistry, 2020)
The endothelium consists of a monolayer of Endothelial Cells (ECs) which form the inner cellular lining of veins, arteries, capillaries and lymphatic vessels. ECs interact with the blood and lymph. The endothelium fulfils ...
Mapping of Protein-Protein Interactions: Web-Based Resources for Revealing Interactomes
(Current Medicinal Chemistry, 2019)
Background: The significant number of protein-protein interactions (PPIs) discovered by harnessing concomitant advances in the fields of sequencing, crystallography, spectrometry and two-hybrid screening suggests astonishing ...
SGLT-2 Inhibitors: The Next-generation Treatment for Type 2 Diabetes Mellitus
(Current Medicinal Chemistry, 2023)
Type 2 diabetes mellitus (T2DM) has become a worldwide concern in recent years, primarily in highly developed Western societies. T2DM causes systemic complications, such as atherosclerotic heart disease, ischemic stroke, ...
Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art
(Current Medicinal Chemistry, 2020)
Lithium is the smallest monovalent cation with many different biological effects. Although lithium is present in the pharmacotherapy of psychiatric illnesses for decades, its precise mechanism of action is still not ...
Polyoxometalates in Biomedicine: Update and Overview
(Current Medicinal Chemistry, 2020)
Background: Polyoxometalates (POMs) are negatively charged metal-oxo clusters of early transition metal ions in high oxidation states (e.g., WVI, MoVI, VV). POMs are of interest in the fields of catalysis, electronics, ...