Synthesis, structural and electrochemical characterization of novel 1,3-ketoureas bearing a ferrocenyl group
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2018
Contributors
Minić, Aleksandra
Jovanović, Jovana P.

Bogdanović, Goran A.

Pejović, Anka

Radulović, Niko
Damljanović, Ivan S.

Stevanović, Dragana D.

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Twenty-two novel 1,3-ketourea derivatives bearing ferrocene moiety were synthesized in good-to-excellent yields (up to 99%) via simple and efficient protocol. This solvent- and catalyst-free synthesis was achieved by additions of different ferrocene-containing Mannich bases - 3-(arylamino)-1-ferrocenyl-propan-1-ones to phenyl isocyanate promoted only by ultrasound irradiations at ambient temperature. All synthesized 1-aryl-3-phenyl-1-(3-ferrocenyl-3-oxopropyl)ureas were characterized by standard spectral data (H-1 NMR, C-13 NMR and IR), and their electrochemical behavior were investigated by cyclic voltammetry. Detailed single-crystal X-ray diffraction analysis of three representative ferrocene-containing 1,3-ketoureas, among which one crystallized with two independent molecules in an asymmetric unit, were done. (C) 2017 Elsevier Ltd. All rights reserved.
Keywords:
Ferrocene / 1,3-Ketoureas derivatives / Solvent-free synthesis / Catalyst-free synthesis / Crystal structureSource:
Polyhedron, 2018, 141, 343-351Projects:
- Novel Electrochemical and Chemical Methods in Synthesis of Organic Compounds of Interest for Medicine and Material Chemistry (RS-172034)
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)