Приказ основних података о документу
Multifunctional hydroxyapatite and poly(D,L-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferol
dc.creator | Ignjatović, Nenad L. | |
dc.creator | Uskoković, Vuk | |
dc.creator | Ajduković, Zorica | |
dc.creator | Uskoković, Dragan | |
dc.date.accessioned | 2018-01-30T10:09:08Z | |
dc.date.available | 2018-01-30T10:09:08Z | |
dc.date.available | 2018-03-06T10:10:31Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0928-4931 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/7571 | |
dc.description.abstract | Cholecalciferol, vitamin D3, plays an important role in bone metabolism by regulating extracellular levels of calcium. Presented here is a study on the effects of the local delivery of cholecalciferol (D3) using nanoparticulate carriers composed of hydroxyapatite (HAp) and poly(D,L-lactide-co-glycolide) (PLGA). Multifunctional nanoparticulate HAp-based powders were prepared for the purpose of: (a) either fast or sustained, local delivery of cholecalciferol, and (b) the secondary, osteoconductive and defect-filling effect of the carrier itself. Two types of HAp-based powders with particles of narrowly dispersed sizes in the nano range were prepared and tested in this study: HAp nanoparticles as direct cholecalciferol delivery agents and HAp nanoparticles coated with cholecalciferol-loaded poly(D,L)-lactide-co-glycolide (HAp/D3/PLGA).Satisfying biocompatibility of particulate systems, when incubated in contact with MC3T3-E1 osteoblastic cells in vitro, was observed for HAp/D3/PLGA and pure HAp. In contrast, an extensively fast release of cholecalciferol from the system comprising HAp nanoparticles coated with cholecalciferol (HAp/D3) triggered necrosis of the osteoblastic cells in vitro. Artificial defects induced in the osteoporotic bone of the rat mandible were successfully reconstructed following implantation of cholecalciferol-coated HAp nanoparticles as well as those comprising HAp nanoparticles coated with cholecalciferol-loaded PLGA (HAp/D3/PLGA). The greatest levels of enhanced angiogenesis, vascularization, osteogenesis and bone structure differentiation were achieved upon the implementation of HAp/D3/PLGA systems. | eng |
dc.format | 33 2 (2013) 943-950 | |
dc.format | application/pdf | |
dc.language | en | |
dc.relation | US National Health Institute grant K99-DE021416 | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Materials Science and Engineering: C | eng |
dc.subject | Multifunctional nano materials | |
dc.subject | Cholecalciferol | |
dc.subject | HAp | |
dc.subject | PLGA | |
dc.subject | Osteogenesis | |
dc.title | Multifunctional hydroxyapatite and poly(D,L-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferol | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Ускоковић, Драган; Ускоковић, Вук; Aјдуковић, Зорица; Игњатовић, Ненад; | |
dc.date.updated | 2020-11-30T10:10:52Z | |
dc.date.updated | 2020-11-30T10:10:52Z | |
dc.citation.volume | 33 | |
dc.citation.issue | 2 | |
dc.citation.spage | 943 | |
dc.citation.epage | 950 | |
dc.identifier.wos | 000315761700053 | |
dc.identifier.doi | 10.1016/j.msec.2012.11.026 | |
dc.citation.rank | M22 | |
dc.description.other | This is the peer-reviewed version of the articleIgnjatović, N., Uskoković, V., Ajduković, Z., Uskoković, D., 2013. Multifunctional hydroxyapatite and poly(d,l-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferol. Materials Science and Engineering: C 33, 943–950. [https://doi.org/10.1016/j.msec.2012.11.026] | |
dc.description.other | Published version: [https://vinar.vin.bg.ac.rs/handle/123456789/7411] | |
dc.type.version | acceptedVersion | |
dc.identifier.scopus | 2-s2.0-84871364442 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/14166/7565.pdf |