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dc.creatorIgnjatović, Nenad L.
dc.creatorWu, Victoria
dc.creatorAjduković, Zorica
dc.creatorMihajilov-Krstev, Tatjana
dc.creatorUskoković, Vuk
dc.creatorUskoković, Dragan
dc.identifier.issn0928-4931 (Print)
dc.identifier.issn1873-0191 (Online)
dc.description.abstractComposite biomaterials comprising nanostructured hydroxyapatite (HAp) have an enormous potential for natural bone tissue reparation, filling and augmentation. Chitosan (Ch) as a naturally derived polymer has many physicochemical and biological properties that make it an attractive material for use in bone tissue engineering. On the other hand, poly-D,L-lactide-co-glycolide (PLGA) is a synthetic polymer with a long history of use in sustained drug delivery and tissue engineering. However, while chitosan can disrupt the cell membrane integrity and may induce blood thrombosis, PLGA releases acidic byproducts that may cause tissue inflammation and interfere with the healing process. One of the strategies to improve the biocompatibility of Ch and PLGA is to combine them with compounds that exhibit complementary properties. In this study we present the synthesis and characterization, as well as in vitro and in vivo analyses of a nanoparticulate form of HAp coated with two different polymeric systems: (a) Ch and (b) a Ch-PLGA polymer blend. Solvent/non-solvent precipitation and freeze-drying were used for synthesis and processing, respectively, whereas thermogravimetry coupled with mass spectrometry was used for phase identification purposes in the coating process. HAp/Ch composite particles exhibited the highest antimicrobial activity against all four microbial strains tested in this work, but after the reconstruction of the bone defect they also caused inflammatory reactions in the newly formed tissue where the defect had lain. Coating HAp with a polymeric blend composed of Ch and PLGA led to a decrease in the reactivity and antimicrobial activity of the composite particles, but also to an increase in the quality of the newly formed bone tissue in the reconstructed defect area.eng
dc.format60 (2016) 357-364
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.relationUnited States National Institutes of Health grant R00-DE021416
dc.sourceMaterials Science and Engineering Ceng
dc.subjectAntimicrobial activity
dc.subjectBone regeneration
dc.subjectTGA-on line MS
dc.titleChitosan-PLGA polymer blends as coatings for hydroxyapatite nanoparticles and their effect on antimicrobial properties, osteoconductivity and regeneration of osseous tissueseng
dcterms.abstractМихајилов-Крстев, Татјана; Ускоковић, Вук; Ускоковић, Драган; Игњатовић, Ненад; Wу, Вицториа; Aјдуковић, Зорица;

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