Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles
2013
Аутори
Najman, StevoPetrović, Dragan
Vučković, Ivan
Živković, J.
Stojanović, S.
Ignjatović, Nenad L.
Uskoković, Dragan
Остала ауторства
Uskoković, DraganКонференцијски прилог
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to investigate the osteogenic potential of freshly isolated adipose tissue-derived mesenchymal stromal/stem cells (ASCs) in bone regeneration of rabbit calvaria defects. ASCs were applied together with calcium phosphate-poly-DL-lactide-co-glycolide (CPPLGA) nanoparticles that are mixed in an appropriately prepared blood clot (BC). Parallelly were analysed defects filled with fragmented adipose tissue (FAT) instead of ASCs, with CP-PLGA in BC, and only with nanoparticles. Bone density in defects was measured after I, III and VI weeks, and histological examination was done after IV and VIII weeks after filling defects. Approach to assisted osteoregeneration which is based on the use of fresh non-induced ASCs has proven to be promising due to the favorable effect on bone regeneration and simplicity of their application.
Кључне речи:
osteogenesis / bone regeneration / adipose / nanoparticlesИзвор:
The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts, 2013, 45-45Издавач:
- Belgrade : Materials Research Society of Serbia
Финансирање / пројекти:
- Молекуларно дизајнирање наночестица контролисаних морфолошких и физичко-хемијских карактеристика и функционалних материјала на њиховој основи (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45004)
Колекције
Институција/група
VinčaTY - CONF AU - Najman, Stevo AU - Petrović, Dragan AU - Vučković, Ivan AU - Živković, J. AU - Stojanović, S. AU - Ignjatović, Nenad L. AU - Uskoković, Dragan PY - 2013 UR - http://dais.sanu.ac.rs/123456789/400 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7419 AB - The aim of this study was to investigate the osteogenic potential of freshly isolated adipose tissue-derived mesenchymal stromal/stem cells (ASCs) in bone regeneration of rabbit calvaria defects. ASCs were applied together with calcium phosphate-poly-DL-lactide-co-glycolide (CPPLGA) nanoparticles that are mixed in an appropriately prepared blood clot (BC). Parallelly were analysed defects filled with fragmented adipose tissue (FAT) instead of ASCs, with CP-PLGA in BC, and only with nanoparticles. Bone density in defects was measured after I, III and VI weeks, and histological examination was done after IV and VIII weeks after filling defects. Approach to assisted osteoregeneration which is based on the use of fresh non-induced ASCs has proven to be promising due to the favorable effect on bone regeneration and simplicity of their application. PB - Belgrade : Materials Research Society of Serbia C3 - The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts T1 - Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles SP - 45 EP - 45 UR - https://hdl.handle.net/21.15107/rcub_vinar_7419 ER -
@conference{ author = "Najman, Stevo and Petrović, Dragan and Vučković, Ivan and Živković, J. and Stojanović, S. and Ignjatović, Nenad L. and Uskoković, Dragan", year = "2013", abstract = "The aim of this study was to investigate the osteogenic potential of freshly isolated adipose tissue-derived mesenchymal stromal/stem cells (ASCs) in bone regeneration of rabbit calvaria defects. ASCs were applied together with calcium phosphate-poly-DL-lactide-co-glycolide (CPPLGA) nanoparticles that are mixed in an appropriately prepared blood clot (BC). Parallelly were analysed defects filled with fragmented adipose tissue (FAT) instead of ASCs, with CP-PLGA in BC, and only with nanoparticles. Bone density in defects was measured after I, III and VI weeks, and histological examination was done after IV and VIII weeks after filling defects. Approach to assisted osteoregeneration which is based on the use of fresh non-induced ASCs has proven to be promising due to the favorable effect on bone regeneration and simplicity of their application.", publisher = "Belgrade : Materials Research Society of Serbia", journal = "The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts", title = "Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles", pages = "45-45", url = "https://hdl.handle.net/21.15107/rcub_vinar_7419" }
Najman, S., Petrović, D., Vučković, I., Živković, J., Stojanović, S., Ignjatović, N. L.,& Uskoković, D.. (2013). Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles. in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts Belgrade : Materials Research Society of Serbia., 45-45. https://hdl.handle.net/21.15107/rcub_vinar_7419
Najman S, Petrović D, Vučković I, Živković J, Stojanović S, Ignjatović NL, Uskoković D. Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles. in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts. 2013;:45-45. https://hdl.handle.net/21.15107/rcub_vinar_7419 .
Najman, Stevo, Petrović, Dragan, Vučković, Ivan, Živković, J., Stojanović, S., Ignjatović, Nenad L., Uskoković, Dragan, "Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles" in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts (2013):45-45, https://hdl.handle.net/21.15107/rcub_vinar_7419 .