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dc.creatorIgnjatović, Nenad L.
dc.creatorAjduković, Zorica
dc.creatorSavić, Vojin
dc.creatorNajman, Stevo
dc.creatorMihailović, Dragan
dc.creatorVasiljević, Perica
dc.creatorStojanović, Zoran S.
dc.creatorUskoković, Vuk
dc.creatorUskoković, Dragan
dc.description.abstractIndications exist that paramagnetic calcium phosphates may be able to promote regeneration of bone faster than their regular, diamagnetic counterparts. In this study, analyzed was the influence of paramagnetic cobalt-substituted hydroxyapatite nanoparticles on osteoporotic alveolar bone regeneration in rats. Simultaneously, biocompatibility of the material was tested in vitro, on osteoblastic MC3T3-E1 and epithelial Caco-2 cells in culture. The material was shown to be biocompatible and nontoxic when added to epithelial monolayers in vitro, while it caused a substantial decrease in the cell viability as well as deformation of the cytoskeleton and cell morphology when incubated with the osteoblastic cells. In the course of 6 months after the implantation of the material containing different amounts of cobalt, ranging from 5 to 12 wt%, in the osteoporotic alveolar bone of the lower jaw, the following parameters were investigated: histopathological parameters, alkaline phosphatase and alveolar bone density. The best result in terms of osteoporotic bone tissue regeneration was observed for hydroxyapatite nanoparticles with the largest content of cobalt ions. The histological analysis showed a high level of reparatory ability of the nanoparticulate material implanted in the bone defect, paralleled by a corresponding increase in the alveolar bone density. The combined effect of growth factors from autologous plasma admixed to cobalt-substituted hydroxyapatite was furthermore shown to have a crucial effect on the augmented osteoporotic bone regeneration upon the implantation of the biomaterial investigated in this study.en
dc.format24 2 (2013) 343-354
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.sourceJournal of Materials Science: Materials in Medicineen
dc.subjectcobalt-substituted hydroxyapatiteen
dc.subjectbone regenerationen
dc.titleNanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bonesen
dcterms.abstractСтојановић, Зоран; Игњатовић, Ненад; Ускоковић, Драган; Aјдуковић, Зорица; Савић, Војин; Најман, Стево; Михаиловић, Драган; Васиљевић, Перица; Ускоковић, Вук;
dc.rights.holder© 2012 Springer Science+Business Media New York
dc.description.otherPeer-reviewed version of the article (Accepted Manuscript or postprint) available at: []

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