Sinteza i dizajniranje strukture i osobina hidroksiapatit-polilaktid kompozitnih biomaterijala
Synthesis and designing of the structure and properties of composite biomaterials hydroxyapatite-polylactides
Autori
Ignjatović, Nenad L.Ostala autorstva
Plavšić, MilenkoUskoković, Dragan
Aleksić, Radoslav
Jovanović, Slobodan
Savić, Vojin
Doktorska teza
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Koštani defekti mogu se reparisati biomaterijalima na bazi sintetskog hidroksiapatita(HAp). U slučaju reparacije koštanih defekata sa prekidom kontinuiteta, neophodno je daupotrebljeni biomaterijal zadovolji biomehaničke uslove. Poboljšanje mehaničkih osobina HApaostvareno je njegovim ojačavanjem biokompatibilnim pofimerima.Predmet ovih istraživanja je sinteza i dizajniranje strukture i osobina kompozitnihbiomaterijala hidroksiapatit-polilaktida. Upotrebom bioresorbilnog poli-l-laktida (PLLA) ibioneresorbilnog HAp-a dobijen je kompozitni biomaterijal HAp/PLLA sa mehaničkimosobinama bliskim prirodnom koštanom tkivu. Mešanjem potpuno rastvorenog PLLA sakomponentom HAp-a, a zatim vakuum uparavanjem, dobijen je visoko porozni kompozit. Ovavrsta kompozita je naknadno dizajnirana hladnim i toplim presovanjem. U ovim istraživanjimaispitan je uticaj presovanja na degradacione promene tokom kompaktiranja, molsku masuPLLA i kompresionu čvrstoću. Definisan je uticaj parametara presovanja, kao što... sutemperatura, pritisak i vreme na poroznost, kompresionu čvrstoću i modul elastičnosti. Ispitanje uticaj veličina čestica HAp-a i molske mase PLLA na analizirane osobine. Mogućnostiprimene kompozitnog biomaterijala HAp/PLLA u realnim, in vivo uslovima ispitane suprimenom FT-IR spektroskopije. Tokom procesa primene dolazi do formiranja novog vezivnogtkiva kolagena, uz stvaranje novih kolagenskih grupa koje su registrovane FT-IRspektroskopijom. Implanti od HAp/PLLA kompozita intraperitonealno su implantirani. a nakon2, 7 i 12 nedelja od impfantacije histopatološki analizirani. Mogućnosti zamene, do sada širokokorišćene, primene autologne kosti u reparacijama koštanog tkiva, takođe je analizirana u ovojdoktorskoj disertaciji.
Bone-defects can be repaired using biomaterials based on synthetic calciumhydroxyapatite(HAp). The bone tissue repair, in the case of broken bone continuity,can successfully be made by a biomaterial of corresponding mechanical properties.Adequate mechanical properties of biocomposite blocks can be reached by reinforcingHAp with biocompatible polymers.The research subject of this study are the synthesis and designing of the structure andproperties of composite biomaterials hydroxyapatite-polylactides Using biocompatibleand bioresorptive poly-L-lactide (PLLA) polymer, HAp/PLLA composite biomaterialconsisting of a non-bioresorptive HAp and bioresorptive PLLA component withmechanical properties similar to those of bones can be produced. Completely dissolvedPLLA with HAp granules gives a mixture, from which, after evaporation in vacuum,HAp/PLLA composite biomaterial of high porosity is formed. The material obtained inthis way can be compacted by hot and cold pressing. In order to investigat...e theinfluence of hot pressing time on the degradation changes, the molecular weight ofPLLA and compressive strength of biocomposite before and after hot pressing havebeen analyzed. The effects of hot pressing parameters such as temperature, pressureand time, on the porosity, compressive strength, elasticity modulus and the mechanismof fracture formation of hot pressed blocks have been investigated, as well as theirdependence on the HAp particle sizes and PLLA molecular weights. In this researchthe bone tissue repair process in vivo using HAp/PLLA composite biomaterial wasstudied by FT-IR spectroscopy. Implants made of HAp/PLLA biocomposites with PLLAwere studied 2, 7 and 12 weeks after being implanted intraperitoneally. Also, a possiblesubstitution of the autologous bone with HAp/PLLA biocomposites, in filling up bonedefects, was investigated.
Ključne reči:
hidroksiapatit-polilaktid / hydroxyapatite-polylactide / kompozitni biomaterijal / sinteza / osobine / toplopresovanje / poroznost / kompresiona čvrstoća / modul elastičnosti / in vitro / in vivo test / composite biomaterials / synthesis / properties / hot pressing / porosity / compressive strength / modulus / in vitro / in vivo testsIzvor:
Универзитет у Београду, 2001Izdavač:
- Универзитет у Београду, Технолошко-металуршки факултет
URI
http://eteze.bg.ac.rs/application/showtheses?thesesId=491https://fedorabg.bg.ac.rs/fedora/get/o:6427/bdef:Content/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=21201167
http://nardus.mpn.gov.rs/123456789/2864
https://vinar.vin.bg.ac.rs/handle/123456789/7252
Kolekcije
Institucija/grupa
VinčaTY - THES AU - Ignjatović, Nenad L. PY - 2001 UR - http://eteze.bg.ac.rs/application/showtheses?thesesId=491 UR - https://fedorabg.bg.ac.rs/fedora/get/o:6427/bdef:Content/download UR - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=21201167 UR - http://nardus.mpn.gov.rs/123456789/2864 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7252 AB - Koštani defekti mogu se reparisati biomaterijalima na bazi sintetskog hidroksiapatita(HAp). U slučaju reparacije koštanih defekata sa prekidom kontinuiteta, neophodno je daupotrebljeni biomaterijal zadovolji biomehaničke uslove. Poboljšanje mehaničkih osobina HApaostvareno je njegovim ojačavanjem biokompatibilnim pofimerima.Predmet ovih istraživanja je sinteza i dizajniranje strukture i osobina kompozitnihbiomaterijala hidroksiapatit-polilaktida. Upotrebom bioresorbilnog poli-l-laktida (PLLA) ibioneresorbilnog HAp-a dobijen je kompozitni biomaterijal HAp/PLLA sa mehaničkimosobinama bliskim prirodnom koštanom tkivu. Mešanjem potpuno rastvorenog PLLA sakomponentom HAp-a, a zatim vakuum uparavanjem, dobijen je visoko porozni kompozit. Ovavrsta kompozita je naknadno dizajnirana hladnim i toplim presovanjem. U ovim istraživanjimaispitan je uticaj presovanja na degradacione promene tokom kompaktiranja, molsku masuPLLA i kompresionu čvrstoću. Definisan je uticaj parametara presovanja, kao što sutemperatura, pritisak i vreme na poroznost, kompresionu čvrstoću i modul elastičnosti. Ispitanje uticaj veličina čestica HAp-a i molske mase PLLA na analizirane osobine. Mogućnostiprimene kompozitnog biomaterijala HAp/PLLA u realnim, in vivo uslovima ispitane suprimenom FT-IR spektroskopije. Tokom procesa primene dolazi do formiranja novog vezivnogtkiva kolagena, uz stvaranje novih kolagenskih grupa koje su registrovane FT-IRspektroskopijom. Implanti od HAp/PLLA kompozita intraperitonealno su implantirani. a nakon2, 7 i 12 nedelja od impfantacije histopatološki analizirani. Mogućnosti zamene, do sada širokokorišćene, primene autologne kosti u reparacijama koštanog tkiva, takođe je analizirana u ovojdoktorskoj disertaciji. AB - Bone-defects can be repaired using biomaterials based on synthetic calciumhydroxyapatite(HAp). The bone tissue repair, in the case of broken bone continuity,can successfully be made by a biomaterial of corresponding mechanical properties.Adequate mechanical properties of biocomposite blocks can be reached by reinforcingHAp with biocompatible polymers.The research subject of this study are the synthesis and designing of the structure andproperties of composite biomaterials hydroxyapatite-polylactides Using biocompatibleand bioresorptive poly-L-lactide (PLLA) polymer, HAp/PLLA composite biomaterialconsisting of a non-bioresorptive HAp and bioresorptive PLLA component withmechanical properties similar to those of bones can be produced. Completely dissolvedPLLA with HAp granules gives a mixture, from which, after evaporation in vacuum,HAp/PLLA composite biomaterial of high porosity is formed. The material obtained inthis way can be compacted by hot and cold pressing. In order to investigate theinfluence of hot pressing time on the degradation changes, the molecular weight ofPLLA and compressive strength of biocomposite before and after hot pressing havebeen analyzed. The effects of hot pressing parameters such as temperature, pressureand time, on the porosity, compressive strength, elasticity modulus and the mechanismof fracture formation of hot pressed blocks have been investigated, as well as theirdependence on the HAp particle sizes and PLLA molecular weights. In this researchthe bone tissue repair process in vivo using HAp/PLLA composite biomaterial wasstudied by FT-IR spectroscopy. Implants made of HAp/PLLA biocomposites with PLLAwere studied 2, 7 and 12 weeks after being implanted intraperitoneally. Also, a possiblesubstitution of the autologous bone with HAp/PLLA biocomposites, in filling up bonedefects, was investigated. PB - Универзитет у Београду, Технолошко-металуршки факултет T2 - Универзитет у Београду T1 - Sinteza i dizajniranje strukture i osobina hidroksiapatit-polilaktid kompozitnih biomaterijala T1 - Synthesis and designing of the structure and properties of composite biomaterials hydroxyapatite-polylactides UR - https://hdl.handle.net/21.15107/rcub_nardus_2864 ER -
@phdthesis{ author = "Ignjatović, Nenad L.", year = "2001", abstract = "Koštani defekti mogu se reparisati biomaterijalima na bazi sintetskog hidroksiapatita(HAp). U slučaju reparacije koštanih defekata sa prekidom kontinuiteta, neophodno je daupotrebljeni biomaterijal zadovolji biomehaničke uslove. Poboljšanje mehaničkih osobina HApaostvareno je njegovim ojačavanjem biokompatibilnim pofimerima.Predmet ovih istraživanja je sinteza i dizajniranje strukture i osobina kompozitnihbiomaterijala hidroksiapatit-polilaktida. Upotrebom bioresorbilnog poli-l-laktida (PLLA) ibioneresorbilnog HAp-a dobijen je kompozitni biomaterijal HAp/PLLA sa mehaničkimosobinama bliskim prirodnom koštanom tkivu. Mešanjem potpuno rastvorenog PLLA sakomponentom HAp-a, a zatim vakuum uparavanjem, dobijen je visoko porozni kompozit. Ovavrsta kompozita je naknadno dizajnirana hladnim i toplim presovanjem. U ovim istraživanjimaispitan je uticaj presovanja na degradacione promene tokom kompaktiranja, molsku masuPLLA i kompresionu čvrstoću. Definisan je uticaj parametara presovanja, kao što sutemperatura, pritisak i vreme na poroznost, kompresionu čvrstoću i modul elastičnosti. Ispitanje uticaj veličina čestica HAp-a i molske mase PLLA na analizirane osobine. Mogućnostiprimene kompozitnog biomaterijala HAp/PLLA u realnim, in vivo uslovima ispitane suprimenom FT-IR spektroskopije. Tokom procesa primene dolazi do formiranja novog vezivnogtkiva kolagena, uz stvaranje novih kolagenskih grupa koje su registrovane FT-IRspektroskopijom. Implanti od HAp/PLLA kompozita intraperitonealno su implantirani. a nakon2, 7 i 12 nedelja od impfantacije histopatološki analizirani. Mogućnosti zamene, do sada širokokorišćene, primene autologne kosti u reparacijama koštanog tkiva, takođe je analizirana u ovojdoktorskoj disertaciji., Bone-defects can be repaired using biomaterials based on synthetic calciumhydroxyapatite(HAp). The bone tissue repair, in the case of broken bone continuity,can successfully be made by a biomaterial of corresponding mechanical properties.Adequate mechanical properties of biocomposite blocks can be reached by reinforcingHAp with biocompatible polymers.The research subject of this study are the synthesis and designing of the structure andproperties of composite biomaterials hydroxyapatite-polylactides Using biocompatibleand bioresorptive poly-L-lactide (PLLA) polymer, HAp/PLLA composite biomaterialconsisting of a non-bioresorptive HAp and bioresorptive PLLA component withmechanical properties similar to those of bones can be produced. Completely dissolvedPLLA with HAp granules gives a mixture, from which, after evaporation in vacuum,HAp/PLLA composite biomaterial of high porosity is formed. The material obtained inthis way can be compacted by hot and cold pressing. In order to investigate theinfluence of hot pressing time on the degradation changes, the molecular weight ofPLLA and compressive strength of biocomposite before and after hot pressing havebeen analyzed. The effects of hot pressing parameters such as temperature, pressureand time, on the porosity, compressive strength, elasticity modulus and the mechanismof fracture formation of hot pressed blocks have been investigated, as well as theirdependence on the HAp particle sizes and PLLA molecular weights. In this researchthe bone tissue repair process in vivo using HAp/PLLA composite biomaterial wasstudied by FT-IR spectroscopy. Implants made of HAp/PLLA biocomposites with PLLAwere studied 2, 7 and 12 weeks after being implanted intraperitoneally. Also, a possiblesubstitution of the autologous bone with HAp/PLLA biocomposites, in filling up bonedefects, was investigated.", publisher = "Универзитет у Београду, Технолошко-металуршки факултет", journal = "Универзитет у Београду", title = "Sinteza i dizajniranje strukture i osobina hidroksiapatit-polilaktid kompozitnih biomaterijala, Synthesis and designing of the structure and properties of composite biomaterials hydroxyapatite-polylactides", url = "https://hdl.handle.net/21.15107/rcub_nardus_2864" }
Ignjatović, N. L.. (2001). Sinteza i dizajniranje strukture i osobina hidroksiapatit-polilaktid kompozitnih biomaterijala. in Универзитет у Београду Универзитет у Београду, Технолошко-металуршки факултет.. https://hdl.handle.net/21.15107/rcub_nardus_2864
Ignjatović NL. Sinteza i dizajniranje strukture i osobina hidroksiapatit-polilaktid kompozitnih biomaterijala. in Универзитет у Београду. 2001;. https://hdl.handle.net/21.15107/rcub_nardus_2864 .
Ignjatović, Nenad L., "Sinteza i dizajniranje strukture i osobina hidroksiapatit-polilaktid kompozitnih biomaterijala" in Универзитет у Београду (2001), https://hdl.handle.net/21.15107/rcub_nardus_2864 .