Show simple item record

dc.creatorRobajac, D.
dc.creatorMasnikosa, Romana
dc.creatorMikovic, Z.
dc.creatorMandie, V.
dc.creatorNedic, O.
dc.date.accessioned2018-03-01T16:23:14Z
dc.date.available2018-03-01T16:23:14Z
dc.date.issued2015
dc.identifier.issn1071-5762 (print)
dc.identifier.issn1029-2470 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/721
dc.description.abstractPlacental insulin receptor (IR) and insulin-like growth factor receptors (IGFRs) are essential for fetal growth. We investigated structural changes of these receptors exposed to increased oxidative stress in mothers diagnosed with diabetes mellitus (DM) or preeclampsia (PE) complicated with intrauterine growth restriction. Increased amount of IR and decreased amounts of IGF1R and IGF2R were found in both pathologies, accompanied by significant elevation in protein carbonyls. When isolated receptors were examined, increased carbonylation of IR and IGF1R in PE placentas was detected, whereas the amounts of carbonylated IR and IGF1R were similar in DM and healthy placentas. Carbonylation status of IGF2R did not change due to pathology, confirming the detrimental role of primary structure and conformation in oxidative susceptibility. Ligand binding was similar in all three groups of samples and did not seem to be affected by receptor oxidation. Since babies delivered by mothers with PE were smaller than the referent population, increased carbonylation of receptors might have affected downstream receptor signaling post-ligand binding.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173042/RS//
dc.rightsrestrictedAccessen
dc.sourceFree Radical Researchen
dc.subjectcarbonylationen
dc.subjectplacental membrane proteinsen
dc.subjectinsulin receptoren
dc.subjectinsulin-like growth factor receptorsen
dc.subjectpreeclampsiaen
dc.subjectdiabetes mellitusen
dc.titleOxidation of placental insulin and insulin-like growth factor receptors in mothers with diabetes mellitus or preeclampsia complicated with intrauterine growth restrictionen
dc.typearticleen
dcterms.abstractМандие, В.; Робајац, Д.; Недиц, О.; Масникоса Романа; Миковиц, З.;
dc.citation.volume49
dc.citation.issue8
dc.citation.spage984
dc.citation.epage989
dc.identifier.wos000360712300008
dc.identifier.doi10.3109/10715762.2015.1020798
dc.citation.rankM22
dc.identifier.pmid25812587
dc.identifier.scopus2-s2.0-84938392883


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record