Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode
Само за регистроване кориснике
2017
Аутори
Švorc, LubomirBorovska, Katarina
Cinkova, Kristina
Stanković, Dalibor M.
Plankova, Alexandra
Чланак у часопису (Објављена верзија)
,
© 2017 Elsevier Ltd.
Метаподаци
Приказ свих података о документуАпстракт
An innovative, rapid and simple electrochemical approach for the reliable quantification of cytostatic drug flutamide (FLU) in various matrices is herein proposed. This platform involves coupling of differential pulse (DPV) and square-wave voltammetry (SWV) with a boron-doped diamond (BDD) electrode as the working electrode and 0.1 M sulphuric acid as the supporting electrolyte. For the first time, the voltammetric profile of FLU was manifested by three irreversible and diffusion-controlled oxidation peaks at + 1.1 (P1), + 1.4 (P2) and + 1.9 V (P3). The analytical performance evaluation was assessed for all three peaks, using both pulse voltammetric techniques with the optimized operating parameters and the highest sensitivity of 1.76 nA/mu M was accomplished for P2 using DPV and 3.54 nA/mu M for P3 using SWV. The corresponding linear concentration ranges were found to be 0.99-42.9 and 4.8-35.5 mu M with the detection limits of 0.42 and 0.18 mu M, respectively. The repeatability varied..., depending on the oxidation peaks of FLU, with the relative standard deviations in the range of 3.3-8.8% and 2.9-9.3% for DPV and SWV, respectively. The proposed electrochemical platform was successfully applied in the analysis of pharmaceutical formulations, spiked human urine and water samples with the significant mean recoveries. Using BDD electrode, the current work establishes an advanced, simple and rapid alternative platform to so far used toxic mercury-based electrodes and time demanding chemically modified electrodes in cytostatic sensing. Besides, BDD electrode represents a comfortable electrochemical sensor for routine analysis in pharmaceutical, clinical and environmental chemistry. (C) 2017 Elsevier Ltd. All rights reserved.
Кључне речи:
cytostatic drug flutamide / boron-doped diamond electrode / electrochemical sensor / differential pulse voltammetry / square-wave voltammetryИзвор:
Electrochimica Acta, 2017, 251, 621-630Финансирање / пројекти:
- Примена унапређених оксидационих процеса и наноструктурисаних оксидних материјала за уклањање загађивача из животне средине, развој и оптимизација инструменталних техника за праћење ефикасности (RS-MESTD-Basic Research (BR or ON)-172030)
- Grant Agency of the Slovak Republic [1/0489/16]
- Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials (EU-FP7-621375)
- Grant scheme for Support of Young Researchers and Excellent Teams of Young Researchers
Напомена:
- 11th International Symposium on Electrochemical Micro and Nanosystem Technologies (EMNT), Aug 17-19, 2016, Royal Belgian Inst Nat Sci, Brussels, Belgium
DOI: 10.1016/j.electacta.2017.08.077
ISSN: 0013-4686
WoS: 000413004200067
Scopus: 2-s2.0-85028691293
Колекције
Институција/група
VinčaTY - JOUR AU - Švorc, Lubomir AU - Borovska, Katarina AU - Cinkova, Kristina AU - Stanković, Dalibor M. AU - Plankova, Alexandra PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7183 AB - An innovative, rapid and simple electrochemical approach for the reliable quantification of cytostatic drug flutamide (FLU) in various matrices is herein proposed. This platform involves coupling of differential pulse (DPV) and square-wave voltammetry (SWV) with a boron-doped diamond (BDD) electrode as the working electrode and 0.1 M sulphuric acid as the supporting electrolyte. For the first time, the voltammetric profile of FLU was manifested by three irreversible and diffusion-controlled oxidation peaks at + 1.1 (P1), + 1.4 (P2) and + 1.9 V (P3). The analytical performance evaluation was assessed for all three peaks, using both pulse voltammetric techniques with the optimized operating parameters and the highest sensitivity of 1.76 nA/mu M was accomplished for P2 using DPV and 3.54 nA/mu M for P3 using SWV. The corresponding linear concentration ranges were found to be 0.99-42.9 and 4.8-35.5 mu M with the detection limits of 0.42 and 0.18 mu M, respectively. The repeatability varied, depending on the oxidation peaks of FLU, with the relative standard deviations in the range of 3.3-8.8% and 2.9-9.3% for DPV and SWV, respectively. The proposed electrochemical platform was successfully applied in the analysis of pharmaceutical formulations, spiked human urine and water samples with the significant mean recoveries. Using BDD electrode, the current work establishes an advanced, simple and rapid alternative platform to so far used toxic mercury-based electrodes and time demanding chemically modified electrodes in cytostatic sensing. Besides, BDD electrode represents a comfortable electrochemical sensor for routine analysis in pharmaceutical, clinical and environmental chemistry. (C) 2017 Elsevier Ltd. All rights reserved. T2 - Electrochimica Acta T1 - Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode VL - 251 SP - 621 EP - 630 DO - 10.1016/j.electacta.2017.08.077 ER -
@article{ author = "Švorc, Lubomir and Borovska, Katarina and Cinkova, Kristina and Stanković, Dalibor M. and Plankova, Alexandra", year = "2017", abstract = "An innovative, rapid and simple electrochemical approach for the reliable quantification of cytostatic drug flutamide (FLU) in various matrices is herein proposed. This platform involves coupling of differential pulse (DPV) and square-wave voltammetry (SWV) with a boron-doped diamond (BDD) electrode as the working electrode and 0.1 M sulphuric acid as the supporting electrolyte. For the first time, the voltammetric profile of FLU was manifested by three irreversible and diffusion-controlled oxidation peaks at + 1.1 (P1), + 1.4 (P2) and + 1.9 V (P3). The analytical performance evaluation was assessed for all three peaks, using both pulse voltammetric techniques with the optimized operating parameters and the highest sensitivity of 1.76 nA/mu M was accomplished for P2 using DPV and 3.54 nA/mu M for P3 using SWV. The corresponding linear concentration ranges were found to be 0.99-42.9 and 4.8-35.5 mu M with the detection limits of 0.42 and 0.18 mu M, respectively. The repeatability varied, depending on the oxidation peaks of FLU, with the relative standard deviations in the range of 3.3-8.8% and 2.9-9.3% for DPV and SWV, respectively. The proposed electrochemical platform was successfully applied in the analysis of pharmaceutical formulations, spiked human urine and water samples with the significant mean recoveries. Using BDD electrode, the current work establishes an advanced, simple and rapid alternative platform to so far used toxic mercury-based electrodes and time demanding chemically modified electrodes in cytostatic sensing. Besides, BDD electrode represents a comfortable electrochemical sensor for routine analysis in pharmaceutical, clinical and environmental chemistry. (C) 2017 Elsevier Ltd. All rights reserved.", journal = "Electrochimica Acta", title = "Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode", volume = "251", pages = "621-630", doi = "10.1016/j.electacta.2017.08.077" }
Švorc, L., Borovska, K., Cinkova, K., Stanković, D. M.,& Plankova, A.. (2017). Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode. in Electrochimica Acta, 251, 621-630. https://doi.org/10.1016/j.electacta.2017.08.077
Švorc L, Borovska K, Cinkova K, Stanković DM, Plankova A. Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode. in Electrochimica Acta. 2017;251:621-630. doi:10.1016/j.electacta.2017.08.077 .
Švorc, Lubomir, Borovska, Katarina, Cinkova, Kristina, Stanković, Dalibor M., Plankova, Alexandra, "Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode" in Electrochimica Acta, 251 (2017):621-630, https://doi.org/10.1016/j.electacta.2017.08.077 . .