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Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones

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2015
RAD2015_Pejic_AntioxidantEnzymesInWomen.pdf (2.616Mb)
Authors
Pejić, Snežana
Todorović, Ana
Stojiljković, Vesna
Gavrilović, Ljubica
Popović, Nataša M.
Pavlović, Ivan
Pajović, Snežana B.
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Abstract
Endometrial hyperplasia complex is gynecological disorder characterized by morphological irregularities of glands shape and size. Antioxidant enzymes (AOE), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), have an essential role in preventing oxidative damage in cell caused by reactive oxygen species (ROS). In this study, we examined the AO status in hyperplastic tissue of patients in menstrual cycle (follicular and luteal phase) and in postmenopause, as well as the relationship between sex hormones and AO parameters. The phase-related activity of GPx and GR in examined patients was significantly different than in healthy women. A significant negative correlation between FSH/LH level and GPx activiy was observed. Endometrial hyperplasias are considered as precancerous lesions and are treated either conservatively or surgicaly, and also by radiation therapy. Since the effects of these therapies are associated with AO and hormonal c...hanges, our results may contribute to the prediction of potential therapeutic efficacy and to selection of the most effective treatment for hyperplasia complex.

Keywords:
endometrial hyperplasia / antioxidant enzymes / steroid hormones
Source:
RAD Conference Proceedings, 2015, 467-470
Projects:
  • Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-41027)
  • Acute coronary syndrome: investigation of vulnerability (plaque, blood and myocardium), optimal treatment and determination of the factors for the prognosis (RS-41022)
  • Molecular and physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stress (RS-173041)
Note:
  • 3rd International Conference on Radiation and Applications in Various Fields of Research (RAD), Jun 08-12, 2015, Budva, Montenegro

ISBN: 978-86-80300-01-6

WoS: 000387979700097

Scopus: 2-s2.0-85057757831
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URI
http://vinar.vin.bg.ac.rs/handle/123456789/7131
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Vinča

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