Fabrication of Biodegradable Poly(Lactic Acid) Particles in Flow-Focusing Glass Capillary Devices
Apstrakt
Monodisperse poly(dl-lactic acid) (PLA) particles with a diameter in the range from 12 to 100 mu m were fabricated in flow focusing glass capillary devices by evaporation of dichloromethane (DCM) from emulsions at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing a small amount of Nile red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the size of the emulsion droplet template indicating that the particle porosity was very low. SEM images revealed that the majority of particle pores are in the sub-micron region but in some instances these pores can reach 3 mu m in diameter. Droplet diameter was influenced by the flow rates of the two phases and the entry diameter of the collection capillary tube; droplet diameters decreased with increasing values of the flow rate ratio of the dispersed to continuous phase to reach constant minimum values at 40-60% orifice diameter. At flow rate rati...os less than 5, jetting can occur, giving rise to large droplets formed by detachment from relatively long jets (similar to 10 times longer than droplet diameter).
Izvor:
Progress in Colloid and Polymer Science, 2012, 139, 111-+Finansiranje / projekti:
- Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom [EP/HO29923/1]
Napomena:
- UK Colloids 2011 - International Colloid and Surface Science Symposium, Jul 04-06, 2011, London, England
DOI: 10.1007/978-3-642-28974-3_19
ISSN: 0340-255X
WoS: 000310177800019
Scopus: 2-s2.0-84870658247
Kolekcije
Institucija/grupa
VinčaTY - CONF AU - Vladisavljević, Goran T. AU - Henry, J. V. AU - Duncanson, Wynter J. AU - Shum, Ho C. AU - Weitz, David A. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6982 AB - Monodisperse poly(dl-lactic acid) (PLA) particles with a diameter in the range from 12 to 100 mu m were fabricated in flow focusing glass capillary devices by evaporation of dichloromethane (DCM) from emulsions at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing a small amount of Nile red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the size of the emulsion droplet template indicating that the particle porosity was very low. SEM images revealed that the majority of particle pores are in the sub-micron region but in some instances these pores can reach 3 mu m in diameter. Droplet diameter was influenced by the flow rates of the two phases and the entry diameter of the collection capillary tube; droplet diameters decreased with increasing values of the flow rate ratio of the dispersed to continuous phase to reach constant minimum values at 40-60% orifice diameter. At flow rate ratios less than 5, jetting can occur, giving rise to large droplets formed by detachment from relatively long jets (similar to 10 times longer than droplet diameter). C3 - Progress in Colloid and Polymer Science T1 - Fabrication of Biodegradable Poly(Lactic Acid) Particles in Flow-Focusing Glass Capillary Devices VL - 139 SP - 111 EP - + DO - 10.1007/978-3-642-28974-3_19 ER -
@conference{ author = "Vladisavljević, Goran T. and Henry, J. V. and Duncanson, Wynter J. and Shum, Ho C. and Weitz, David A.", year = "2012", abstract = "Monodisperse poly(dl-lactic acid) (PLA) particles with a diameter in the range from 12 to 100 mu m were fabricated in flow focusing glass capillary devices by evaporation of dichloromethane (DCM) from emulsions at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing a small amount of Nile red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the size of the emulsion droplet template indicating that the particle porosity was very low. SEM images revealed that the majority of particle pores are in the sub-micron region but in some instances these pores can reach 3 mu m in diameter. Droplet diameter was influenced by the flow rates of the two phases and the entry diameter of the collection capillary tube; droplet diameters decreased with increasing values of the flow rate ratio of the dispersed to continuous phase to reach constant minimum values at 40-60% orifice diameter. At flow rate ratios less than 5, jetting can occur, giving rise to large droplets formed by detachment from relatively long jets (similar to 10 times longer than droplet diameter).", journal = "Progress in Colloid and Polymer Science", title = "Fabrication of Biodegradable Poly(Lactic Acid) Particles in Flow-Focusing Glass Capillary Devices", volume = "139", pages = "111-+", doi = "10.1007/978-3-642-28974-3_19" }
Vladisavljević, G. T., Henry, J. V., Duncanson, W. J., Shum, H. C.,& Weitz, D. A.. (2012). Fabrication of Biodegradable Poly(Lactic Acid) Particles in Flow-Focusing Glass Capillary Devices. in Progress in Colloid and Polymer Science, 139, 111-+. https://doi.org/10.1007/978-3-642-28974-3_19
Vladisavljević GT, Henry JV, Duncanson WJ, Shum HC, Weitz DA. Fabrication of Biodegradable Poly(Lactic Acid) Particles in Flow-Focusing Glass Capillary Devices. in Progress in Colloid and Polymer Science. 2012;139:111-+. doi:10.1007/978-3-642-28974-3_19 .
Vladisavljević, Goran T., Henry, J. V., Duncanson, Wynter J., Shum, Ho C., Weitz, David A., "Fabrication of Biodegradable Poly(Lactic Acid) Particles in Flow-Focusing Glass Capillary Devices" in Progress in Colloid and Polymer Science, 139 (2012):111-+, https://doi.org/10.1007/978-3-642-28974-3_19 . .