The Optimization of Oligonucleotide Conjugation Onto Gold Nanoparticles for Biodetection
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In this paper we present the optimization procedure for the application of gold nanoparticles as a system for the detection of oligonucleotides. The gold nanoparticles have been conjugated to a pair of 5-alkanethiol-modified 20 base oligonucleotides, designed to align in a tail-to-head manner. Upon hybridization with the complementary target, the plasmon region of the spectra registers a large red-shift, thus forming a reliable colorimetric system for the detection of oligonucleotides.
- European Commission Programs NANOMY , SANTS 
- International Semiconductor Conference, 32nd International Semiconductor Conference, Oct 12-14, 2009, Sinaia, Romania