Na+/K+-ATPase: Activity and inhibition
AuthorsČolović, Mirjana B.
Krstić, Danijela Z.
Vujačić, Ana V.
Vasić, Vesna M.
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The aim of the study was to give an overview of the mechanism of inhibition of Na+/K+-ATPase activity induced by some specific and non specific inhibitors. For this purpose, the effects of some ouabain like compounds (digoxin, gitoxin), noble metals complexes ([PtCl2DMSO2], [AuCl4](-), [PdCl4](2-), [PdCl(dien)](+), [PdCl(Me(4)dien)](+)), transition metal ions (Cu2+, Zn2+, Fe2+, Co2+), and heavy metal ions (Hg2+, Pb2+, Cd2+) on the activity of Na+/K+-ATPase from rat synaptic plasma membranes (SPM), porcine cerebral cortex and human erythrocytes were discussed.
Source:Russian Journal of Physical Chemistry A, 2009, 83, 9, 1602-1608
- 9th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Sep 24-26, 2008, Belgrade, Serbia