Biokompatibilni i bioadhezivni hidrogelovi na bazi 2-hidroksietil metakrilata, monofunkcionalizovanih poli(alkilen glikol)a i itakonske kiseline
Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid
Апстракт
Radikalnom kopolimerizacijom 2-hidroksietil metakrilata (HEMA), itakonske kiseline (IK) i četiri tipa poli(alkilen glikol) (met)akrilata (Bisomera-BIS) dobijeni su novi poli(BIS/HEMA/IK) hidrogelovi, u smeši voda/etanol kao rastvaraču. Ispitan je uticaj tipa Bisomera na bubrenje u puferima pH 2,20-7,40, u uslovima sličnim biološkim fluidima. Takođe, praćen je i uticaj na mehanička svojstva, morfologiju i termičko ponašanje dobijenih gelova. Testiranje biokompatibilnosti in vitro na poli (BIS/HEMA/IK) hidrogelovima pokazuje da nema ćelijske sličnosti, niti hemlitičke aktivnosti. Gelovi poseduju zadovoljavajuću bioadhezivnost.
New types of hydrogels were prepared by the radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid and four different poly(alkylene glycol) (meth)acrylate components (Bisomers) in a water/ethanol mixture as solvent. The polymers swell in water at 25 degrees C to yield homogeneous transparent hydrogels. All the hydrogels displayed pH sensitive behavior in buffers of the pH range from 2.20 to 7.40, under conditions similar to those of biological fluids. The presence of these two comonomers, which were added to HEMA, increased the swelling degree of the hydrogels and gave gels with better elasticity. The hydrogels were thermally stable in the vicinity of the physiological temperature (37 degrees C). The copolymer containing pure poly(ethylene glycol) acrylate units generally had the best properties. The tests performed on the hydrogels confirmed that they were neither hernolytic nor cytotoxic. The copolymer samples showed better cell viability and less hemolytic activity t...han the PHEMA sample, confirming the assumption that poly(alkylene glycols) improve the biocompatibility of hydrogels. Due to their swelling and mechanical characteristics, as well as the very good biocompatibility and bioadhesive properties, poly(Bisomer/HEMA/IA) hydrogels are promising for utilization in the field of biomedicals, especially for the controlled release of drugs.
Кључне речи:
2-hydroxyethyl methacrylate / itaconic acid / poly(alkylene glycol) (meth)acrylates / hydrogels / hemolytic activity / 2-hidroksietil metakrilat / itakonska kiselina / poli(alkilen glikol) / (met)akrilati / hidrogelovi / hemolitička aktivnostИзвор:
Hemijska industrija, 2007, 61, 2, 83-89Напомена:
- 5th Young Researchers Seminar, Dec 25-26, 2006, Belgrade, Serbia
Колекције
Институција/група
VinčaTY - JOUR AU - Mićić, Maja M. AU - Tomić, Simonida Lj. AU - Filipović, Jovanka M. AU - Suljovrujić, Edin H. PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6742 AB - Radikalnom kopolimerizacijom 2-hidroksietil metakrilata (HEMA), itakonske kiseline (IK) i četiri tipa poli(alkilen glikol) (met)akrilata (Bisomera-BIS) dobijeni su novi poli(BIS/HEMA/IK) hidrogelovi, u smeši voda/etanol kao rastvaraču. Ispitan je uticaj tipa Bisomera na bubrenje u puferima pH 2,20-7,40, u uslovima sličnim biološkim fluidima. Takođe, praćen je i uticaj na mehanička svojstva, morfologiju i termičko ponašanje dobijenih gelova. Testiranje biokompatibilnosti in vitro na poli (BIS/HEMA/IK) hidrogelovima pokazuje da nema ćelijske sličnosti, niti hemlitičke aktivnosti. Gelovi poseduju zadovoljavajuću bioadhezivnost. AB - New types of hydrogels were prepared by the radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid and four different poly(alkylene glycol) (meth)acrylate components (Bisomers) in a water/ethanol mixture as solvent. The polymers swell in water at 25 degrees C to yield homogeneous transparent hydrogels. All the hydrogels displayed pH sensitive behavior in buffers of the pH range from 2.20 to 7.40, under conditions similar to those of biological fluids. The presence of these two comonomers, which were added to HEMA, increased the swelling degree of the hydrogels and gave gels with better elasticity. The hydrogels were thermally stable in the vicinity of the physiological temperature (37 degrees C). The copolymer containing pure poly(ethylene glycol) acrylate units generally had the best properties. The tests performed on the hydrogels confirmed that they were neither hernolytic nor cytotoxic. The copolymer samples showed better cell viability and less hemolytic activity than the PHEMA sample, confirming the assumption that poly(alkylene glycols) improve the biocompatibility of hydrogels. Due to their swelling and mechanical characteristics, as well as the very good biocompatibility and bioadhesive properties, poly(Bisomer/HEMA/IA) hydrogels are promising for utilization in the field of biomedicals, especially for the controlled release of drugs. T2 - Hemijska industrija T1 - Biokompatibilni i bioadhezivni hidrogelovi na bazi 2-hidroksietil metakrilata, monofunkcionalizovanih poli(alkilen glikol)a i itakonske kiseline T1 - Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid VL - 61 IS - 2 SP - 83 EP - 89 DO - 10.2298/HEMIND0702083M ER -
@article{ author = "Mićić, Maja M. and Tomić, Simonida Lj. and Filipović, Jovanka M. and Suljovrujić, Edin H.", year = "2007", abstract = "Radikalnom kopolimerizacijom 2-hidroksietil metakrilata (HEMA), itakonske kiseline (IK) i četiri tipa poli(alkilen glikol) (met)akrilata (Bisomera-BIS) dobijeni su novi poli(BIS/HEMA/IK) hidrogelovi, u smeši voda/etanol kao rastvaraču. Ispitan je uticaj tipa Bisomera na bubrenje u puferima pH 2,20-7,40, u uslovima sličnim biološkim fluidima. Takođe, praćen je i uticaj na mehanička svojstva, morfologiju i termičko ponašanje dobijenih gelova. Testiranje biokompatibilnosti in vitro na poli (BIS/HEMA/IK) hidrogelovima pokazuje da nema ćelijske sličnosti, niti hemlitičke aktivnosti. Gelovi poseduju zadovoljavajuću bioadhezivnost., New types of hydrogels were prepared by the radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid and four different poly(alkylene glycol) (meth)acrylate components (Bisomers) in a water/ethanol mixture as solvent. The polymers swell in water at 25 degrees C to yield homogeneous transparent hydrogels. All the hydrogels displayed pH sensitive behavior in buffers of the pH range from 2.20 to 7.40, under conditions similar to those of biological fluids. The presence of these two comonomers, which were added to HEMA, increased the swelling degree of the hydrogels and gave gels with better elasticity. The hydrogels were thermally stable in the vicinity of the physiological temperature (37 degrees C). The copolymer containing pure poly(ethylene glycol) acrylate units generally had the best properties. The tests performed on the hydrogels confirmed that they were neither hernolytic nor cytotoxic. The copolymer samples showed better cell viability and less hemolytic activity than the PHEMA sample, confirming the assumption that poly(alkylene glycols) improve the biocompatibility of hydrogels. Due to their swelling and mechanical characteristics, as well as the very good biocompatibility and bioadhesive properties, poly(Bisomer/HEMA/IA) hydrogels are promising for utilization in the field of biomedicals, especially for the controlled release of drugs.", journal = "Hemijska industrija", title = "Biokompatibilni i bioadhezivni hidrogelovi na bazi 2-hidroksietil metakrilata, monofunkcionalizovanih poli(alkilen glikol)a i itakonske kiseline, Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid", volume = "61", number = "2", pages = "83-89", doi = "10.2298/HEMIND0702083M" }
Mićić, M. M., Tomić, S. Lj., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Biokompatibilni i bioadhezivni hidrogelovi na bazi 2-hidroksietil metakrilata, monofunkcionalizovanih poli(alkilen glikol)a i itakonske kiseline. in Hemijska industrija, 61(2), 83-89. https://doi.org/10.2298/HEMIND0702083M
Mićić MM, Tomić SL, Filipović JM, Suljovrujić EH. Biokompatibilni i bioadhezivni hidrogelovi na bazi 2-hidroksietil metakrilata, monofunkcionalizovanih poli(alkilen glikol)a i itakonske kiseline. in Hemijska industrija. 2007;61(2):83-89. doi:10.2298/HEMIND0702083M .
Mićić, Maja M., Tomić, Simonida Lj., Filipović, Jovanka M., Suljovrujić, Edin H., "Biokompatibilni i bioadhezivni hidrogelovi na bazi 2-hidroksietil metakrilata, monofunkcionalizovanih poli(alkilen glikol)a i itakonske kiseline" in Hemijska industrija, 61, no. 2 (2007):83-89, https://doi.org/10.2298/HEMIND0702083M . .