Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells
Само за регистроване кориснике
2007
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Naturally occurring phytoanthracycline, aloin, was used to radiosensitize HeLaS3 human cervix carcinoma cells. The results indicated that the cytotoxic adjuvant effect of aloin was synergistic with gammaionizing radiation at all drug concentrations and comparable to the cytotoxicity of 5-10 Gy ionizing radiation alone. Radiosensitization of HeLaS3 cells was achieved by 60 mu M aloin, which reduced the IC50 dose of ionizing radiation from 3.4 to 2 Gy. Ionizing radiation and aloin alone or in combination are shown to cause perturbation of the HeLaS3 cell-cycle and increase the percentage of cells in the DNA synthesis (S) phase of the cell cycle. While either of the agents applied alone causes programmed cell death by apoptosis, the simultaneous cell damage by both agents through the altered redox balance compromised cell capacity to conduct this program and led to synergic cytotoxic cell death by necrosis.
Извор:
Russian Journal of Physical Chemistry A, 2007, 81, 9, 1463-1466Финансирање / пројекти:
- Ministry of Science and Environmental Protection of the Republic of Serbia [143042B]
Напомена:
- 8th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Sep 26-29, 2006, Belgrade, Serbia
DOI: 10.1134/S0036024407090221
ISSN: 0036-0244; 1531-863X
WoS: 000253706400022
Scopus: 2-s2.0-34548484773
Колекције
Институција/група
VinčaTY - JOUR AU - Nićiforović, Ana AU - Adžić, Miroslav AU - Zarić, Božidarka AU - Radojčić, Marija PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6723 AB - Naturally occurring phytoanthracycline, aloin, was used to radiosensitize HeLaS3 human cervix carcinoma cells. The results indicated that the cytotoxic adjuvant effect of aloin was synergistic with gammaionizing radiation at all drug concentrations and comparable to the cytotoxicity of 5-10 Gy ionizing radiation alone. Radiosensitization of HeLaS3 cells was achieved by 60 mu M aloin, which reduced the IC50 dose of ionizing radiation from 3.4 to 2 Gy. Ionizing radiation and aloin alone or in combination are shown to cause perturbation of the HeLaS3 cell-cycle and increase the percentage of cells in the DNA synthesis (S) phase of the cell cycle. While either of the agents applied alone causes programmed cell death by apoptosis, the simultaneous cell damage by both agents through the altered redox balance compromised cell capacity to conduct this program and led to synergic cytotoxic cell death by necrosis. T2 - Russian Journal of Physical Chemistry A T1 - Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells VL - 81 IS - 9 SP - 1463 EP - 1466 DO - 10.1134/S0036024407090221 ER -
@article{ author = "Nićiforović, Ana and Adžić, Miroslav and Zarić, Božidarka and Radojčić, Marija", year = "2007", abstract = "Naturally occurring phytoanthracycline, aloin, was used to radiosensitize HeLaS3 human cervix carcinoma cells. The results indicated that the cytotoxic adjuvant effect of aloin was synergistic with gammaionizing radiation at all drug concentrations and comparable to the cytotoxicity of 5-10 Gy ionizing radiation alone. Radiosensitization of HeLaS3 cells was achieved by 60 mu M aloin, which reduced the IC50 dose of ionizing radiation from 3.4 to 2 Gy. Ionizing radiation and aloin alone or in combination are shown to cause perturbation of the HeLaS3 cell-cycle and increase the percentage of cells in the DNA synthesis (S) phase of the cell cycle. While either of the agents applied alone causes programmed cell death by apoptosis, the simultaneous cell damage by both agents through the altered redox balance compromised cell capacity to conduct this program and led to synergic cytotoxic cell death by necrosis.", journal = "Russian Journal of Physical Chemistry A", title = "Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells", volume = "81", number = "9", pages = "1463-1466", doi = "10.1134/S0036024407090221" }
Nićiforović, A., Adžić, M., Zarić, B.,& Radojčić, M.. (2007). Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells. in Russian Journal of Physical Chemistry A, 81(9), 1463-1466. https://doi.org/10.1134/S0036024407090221
Nićiforović A, Adžić M, Zarić B, Radojčić M. Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells. in Russian Journal of Physical Chemistry A. 2007;81(9):1463-1466. doi:10.1134/S0036024407090221 .
Nićiforović, Ana, Adžić, Miroslav, Zarić, Božidarka, Radojčić, Marija, "Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells" in Russian Journal of Physical Chemistry A, 81, no. 9 (2007):1463-1466, https://doi.org/10.1134/S0036024407090221 . .