The stabilizer influence on morphological characteristics of poly-(DL-lactide-co-glycolide) nanospheres
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Copolymer poly(D,L-lactide-co-glycolide) is used for obtaining the systems for controlled delivery of medicaments. Its specific characteristics make it suitable for various researches where its synthesis is performed in different ways. Using the system for controlled delivery of medicaments, an equal concentration of the medicament is achieved in the body throughout an extended period of time and it has advantages over the conventional methods. In this paper we present a new solvent/non-solvent chemical method for obtaining DLPLG nanospheres. In the experiment various stabilizers were used in order to examine their influence on morphological characteristics of DLPLG particles. The samples were characterized by Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM) and Stereological analysis.
Keywords:drug delivery / nanospheres / poly-(DL-lactide-co-glycolide) / polyvinyl alcohol / polyvinyl pyrrolidone / stabilizers / stereological analysis
Source:Materials Science Forum, 2007, 555, 447-+
- Research Trends in Contemporary Materials Science, 8th Conference of the Yugoslav-Materials-Research-Society (Yu-MRS), Sep 04-08, 2006, Herceg Novi, Montenegro