The effect of repeated physical exercise on hippocampus and brain cortex in stressed rats
Abstract
Sensitivity of target cells to glucocorticoids is regulated by the expression of intracellular glucocorticoid receptor (GR), which mediates the effects of glucocorticoids. The level of GR and of its nuclear transporter protein 70 (Hsp70) were followed in hippocampus and brain cortex of adult Wistar rat males exposed to acute (immobilization, cold) and chronic (social isolation, isolation, and 15 min daily swimming) stress or their combinations. Changes in plasma levels of adenocorticotropic hormone and corticosterone were also studied. A significant decrease in cytosol GR and Hsp70 was observed after acute stress. Opposite to that, chronic stress led to negligible changes in both cytosol GR and Hsp70 levels. Isolation, as chronic psychosocial stressor, caused reduced responsiveness to novel acute stressors, judged by the cytosol GR and Hsp70 levels. This was not observed if chronic isolation was combined with 15 min daily swimming prior to acute exposure to immobilization. The data sug...gest that repeated physical exercise may, at least in some cases, diminish detrimental effects of chronic social isolation on limbic-hypothalamic-pituitary-adrenocortical axis, as judged by the levels of GR and Hsp70 in the Wistar rat brain.
Keywords:
neuroendocrine stress / glucocorticoid receptor / heat shock protein 70 / rat brainSource:
Annals of the New York Academy of Sciences, 2007, 1096, 207-219Note:
- Cell Signaling World 2006 Conference, Jan 25-28, 2006, Luxembourg, Luxembourg
DOI: 10.1196/annals.1397.087
ISSN: 0077-8923
PubMed: 17405932
WoS: 000245947600023
Scopus: 2-s2.0-34247248330
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VinčaTY - JOUR AU - Filipović, Dragana AU - Gavrilović, Ljubica AU - Dronjak, Slađana AU - Radojčić, Marija PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6649 AB - Sensitivity of target cells to glucocorticoids is regulated by the expression of intracellular glucocorticoid receptor (GR), which mediates the effects of glucocorticoids. The level of GR and of its nuclear transporter protein 70 (Hsp70) were followed in hippocampus and brain cortex of adult Wistar rat males exposed to acute (immobilization, cold) and chronic (social isolation, isolation, and 15 min daily swimming) stress or their combinations. Changes in plasma levels of adenocorticotropic hormone and corticosterone were also studied. A significant decrease in cytosol GR and Hsp70 was observed after acute stress. Opposite to that, chronic stress led to negligible changes in both cytosol GR and Hsp70 levels. Isolation, as chronic psychosocial stressor, caused reduced responsiveness to novel acute stressors, judged by the cytosol GR and Hsp70 levels. This was not observed if chronic isolation was combined with 15 min daily swimming prior to acute exposure to immobilization. The data suggest that repeated physical exercise may, at least in some cases, diminish detrimental effects of chronic social isolation on limbic-hypothalamic-pituitary-adrenocortical axis, as judged by the levels of GR and Hsp70 in the Wistar rat brain. T2 - Annals of the New York Academy of Sciences T1 - The effect of repeated physical exercise on hippocampus and brain cortex in stressed rats VL - 1096 SP - 207 EP - 219 DO - 10.1196/annals.1397.087 ER -
@article{ author = "Filipović, Dragana and Gavrilović, Ljubica and Dronjak, Slađana and Radojčić, Marija", year = "2007", abstract = "Sensitivity of target cells to glucocorticoids is regulated by the expression of intracellular glucocorticoid receptor (GR), which mediates the effects of glucocorticoids. The level of GR and of its nuclear transporter protein 70 (Hsp70) were followed in hippocampus and brain cortex of adult Wistar rat males exposed to acute (immobilization, cold) and chronic (social isolation, isolation, and 15 min daily swimming) stress or their combinations. Changes in plasma levels of adenocorticotropic hormone and corticosterone were also studied. A significant decrease in cytosol GR and Hsp70 was observed after acute stress. Opposite to that, chronic stress led to negligible changes in both cytosol GR and Hsp70 levels. Isolation, as chronic psychosocial stressor, caused reduced responsiveness to novel acute stressors, judged by the cytosol GR and Hsp70 levels. This was not observed if chronic isolation was combined with 15 min daily swimming prior to acute exposure to immobilization. The data suggest that repeated physical exercise may, at least in some cases, diminish detrimental effects of chronic social isolation on limbic-hypothalamic-pituitary-adrenocortical axis, as judged by the levels of GR and Hsp70 in the Wistar rat brain.", journal = "Annals of the New York Academy of Sciences", title = "The effect of repeated physical exercise on hippocampus and brain cortex in stressed rats", volume = "1096", pages = "207-219", doi = "10.1196/annals.1397.087" }
Filipović, D., Gavrilović, L., Dronjak, S.,& Radojčić, M.. (2007). The effect of repeated physical exercise on hippocampus and brain cortex in stressed rats. in Annals of the New York Academy of Sciences, 1096, 207-219. https://doi.org/10.1196/annals.1397.087
Filipović D, Gavrilović L, Dronjak S, Radojčić M. The effect of repeated physical exercise on hippocampus and brain cortex in stressed rats. in Annals of the New York Academy of Sciences. 2007;1096:207-219. doi:10.1196/annals.1397.087 .
Filipović, Dragana, Gavrilović, Ljubica, Dronjak, Slađana, Radojčić, Marija, "The effect of repeated physical exercise on hippocampus and brain cortex in stressed rats" in Annals of the New York Academy of Sciences, 1096 (2007):207-219, https://doi.org/10.1196/annals.1397.087 . .