CuZn superoxide dismutase in the hippocampus and brain cortex of rats exposed to various stress conditions
Abstract
The CuZn superoxide dismutase (CuZnSOD) protein expression in hippocampus and brain cortex of Wistar male rats exposed to acute, chronic, or combined stress was followed by Western immunoblotting. The CuZnSOD was significantly induced by acute stressors but not by chronic or combined stress conditions. As CuZnSOD expression is regulated by stress steroids, the lack of SOD upregulation under chronic stress and its moderate upregulation in combined stress may lead to inefficient ROS defense and increased oxidative damage of brain tissues under the stress conditions.
Keywords:
CuZnSOD / stress / hippocampus / brain cortex / Wistar ratSource:
Annals of the New York Academy of Sciences, 2005, 1048, 366-368Note:
- 22nd International Biophysics Symposium, Oct 09-14, 2004, Belgrade, Serbia
DOI: 10.1196/annals.1342.040
ISSN: 0077-8923
PubMed: 16154954
WoS: 000233712300038
Scopus: 2-s2.0-25144507030
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VinčaTY - JOUR AU - Filipović, Dragana AU - Radojčić, Marija PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6552 AB - The CuZn superoxide dismutase (CuZnSOD) protein expression in hippocampus and brain cortex of Wistar male rats exposed to acute, chronic, or combined stress was followed by Western immunoblotting. The CuZnSOD was significantly induced by acute stressors but not by chronic or combined stress conditions. As CuZnSOD expression is regulated by stress steroids, the lack of SOD upregulation under chronic stress and its moderate upregulation in combined stress may lead to inefficient ROS defense and increased oxidative damage of brain tissues under the stress conditions. T2 - Annals of the New York Academy of Sciences T1 - CuZn superoxide dismutase in the hippocampus and brain cortex of rats exposed to various stress conditions VL - 1048 SP - 366 EP - 368 DO - 10.1196/annals.1342.040 ER -
@article{ author = "Filipović, Dragana and Radojčić, Marija", year = "2005", abstract = "The CuZn superoxide dismutase (CuZnSOD) protein expression in hippocampus and brain cortex of Wistar male rats exposed to acute, chronic, or combined stress was followed by Western immunoblotting. The CuZnSOD was significantly induced by acute stressors but not by chronic or combined stress conditions. As CuZnSOD expression is regulated by stress steroids, the lack of SOD upregulation under chronic stress and its moderate upregulation in combined stress may lead to inefficient ROS defense and increased oxidative damage of brain tissues under the stress conditions.", journal = "Annals of the New York Academy of Sciences", title = "CuZn superoxide dismutase in the hippocampus and brain cortex of rats exposed to various stress conditions", volume = "1048", pages = "366-368", doi = "10.1196/annals.1342.040" }
Filipović, D.,& Radojčić, M.. (2005). CuZn superoxide dismutase in the hippocampus and brain cortex of rats exposed to various stress conditions. in Annals of the New York Academy of Sciences, 1048, 366-368. https://doi.org/10.1196/annals.1342.040
Filipović D, Radojčić M. CuZn superoxide dismutase in the hippocampus and brain cortex of rats exposed to various stress conditions. in Annals of the New York Academy of Sciences. 2005;1048:366-368. doi:10.1196/annals.1342.040 .
Filipović, Dragana, Radojčić, Marija, "CuZn superoxide dismutase in the hippocampus and brain cortex of rats exposed to various stress conditions" in Annals of the New York Academy of Sciences, 1048 (2005):366-368, https://doi.org/10.1196/annals.1342.040 . .