Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players
2015
Authors
Baralic, IvanaAnđelković, Marija
Đorđević, Brižita
Dikic, Nenad
Radivojevic, Nenad
Suzin-Zivkovic, Violeta
Radojević-Škodrić, Sanja
Pejić, Snežana
Article (Published version)
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Show full item recordAbstract
The physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemi...c inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.
Source:
Evidence-based Complementary and Alternative Medicine / eCAM, 2015Funding / projects:
- Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46001)
- Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
DOI: 10.1155/2015/783761
ISSN: 1741-427X; 1741-4288
WoS: 000357200400001
Scopus: 2-s2.0-84934344013
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VinčaTY - JOUR AU - Baralic, Ivana AU - Anđelković, Marija AU - Đorđević, Brižita AU - Dikic, Nenad AU - Radivojevic, Nenad AU - Suzin-Zivkovic, Violeta AU - Radojević-Škodrić, Sanja AU - Pejić, Snežana PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/639 AB - The physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation. T2 - Evidence-based Complementary and Alternative Medicine / eCAM T1 - Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players DO - 10.1155/2015/783761 ER -
@article{ author = "Baralic, Ivana and Anđelković, Marija and Đorđević, Brižita and Dikic, Nenad and Radivojevic, Nenad and Suzin-Zivkovic, Violeta and Radojević-Škodrić, Sanja and Pejić, Snežana", year = "2015", abstract = "The physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.", journal = "Evidence-based Complementary and Alternative Medicine / eCAM", title = "Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players", doi = "10.1155/2015/783761" }
Baralic, I., Anđelković, M., Đorđević, B., Dikic, N., Radivojevic, N., Suzin-Zivkovic, V., Radojević-Škodrić, S.,& Pejić, S.. (2015). Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. in Evidence-based Complementary and Alternative Medicine / eCAM. https://doi.org/10.1155/2015/783761
Baralic I, Anđelković M, Đorđević B, Dikic N, Radivojevic N, Suzin-Zivkovic V, Radojević-Škodrić S, Pejić S. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. in Evidence-based Complementary and Alternative Medicine / eCAM. 2015;. doi:10.1155/2015/783761 .
Baralic, Ivana, Anđelković, Marija, Đorđević, Brižita, Dikic, Nenad, Radivojevic, Nenad, Suzin-Zivkovic, Violeta, Radojević-Škodrić, Sanja, Pejić, Snežana, "Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players" in Evidence-based Complementary and Alternative Medicine / eCAM (2015), https://doi.org/10.1155/2015/783761 . .