Photochemical degradation of solid-state nisoldipine monitored by HPLC
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The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). (C) 2003 Elsevier Science B.V. All rights reserved.
Keywords:nisoldipine / photochemical degradation / illumination
Source:Journal of Pharmaceutical and Biomedical Analysis, 2003, 32, 4-5, 929-935
- Joint Meeting of the 7th International Symposium on Drug Analysis/13th International Symposium on Pharmaceutical and Biomedial Analysis, Apr 21-25, 2002, Brugge, Belgium