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dc.creatorPagano, Giovanni
dc.creatorTalamanca, Annarita Aiello
dc.creatorCastello, Giuseppe
dc.creatorCordero, Mario D.
dc.creatord'Ischia, Marco
dc.creatorGadaleta, Maria Nicola
dc.creatorPallardo, Federico V.
dc.creatorPetrović, Sandra
dc.creatorTiano, Luca
dc.creatorZatterale, Adriana
dc.date.accessioned2018-03-01T15:14:20Z
dc.date.available2018-03-01T15:14:20Z
dc.date.issued2014
dc.identifier.issn1422-0067 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/60
dc.description.abstractAn extensive number of pathologies are associated with mitochondrial dysfunction (MDF) and oxidative stress (OS). Thus, mitochondrial cofactors termed mitochondrial nutrients (MN), such as alpha-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and L-carnitine (CARN) (or its derivatives) have been tested in a number of clinical trials, and this review is focused on the use of MN-based clinical trials. The papers reporting on MN-based clinical trials were retrieved in MedLine up to July 2014, and evaluated for the following endpoints: (a) treated diseases; (b) dosages, number of enrolled patients and duration of treatment; (c) trial success for each MN or MN combinations as reported by authors. The reports satisfying the above endpoints included total numbers of trials and frequencies of randomized, controlled studies, i.e., 81 trials testing ALA, 107 reports testing CoQ10, and 74 reports testing CARN, while only 7 reports were retrieved testing double MN associations, while no report was found testing a triple MN combination. A total of 28 reports tested MN associations with classical antioxidants, such as antioxidant nutrients or drugs. Combinations of MN showed better outcomes than individual MN, suggesting forthcoming clinical studies. The criteria in study design and monitoring MN-based clinical trials are discussed.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173046/RS//
dc.rightsopenAccessen
dc.sourceInternational Journal of Molecular Sciencesen
dc.subjectmitochondrial nutrientsen
dc.subjectmitochondrial dysfunctionen
dc.subjectoxidative stressen
dc.subjectoxidative phosphorylationen
dc.subjectKrebs cycleen
dc.titleCurrent Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trialsen
dc.typereviewen
dcterms.abstractд'Исцхиа, Марцо; Петровић, Сандра; Паллардо, Федерицо В.; Цордеро, Марио Д.; Гадалета, Мариа Ницола; Таламанца, Aннарита Aиелло; Тиано, Луца; Цастелло, Гиусеппе; Пагано, Гиованни; Заттерале, Aдриана;
dc.citation.volume15
dc.citation.issue11
dc.citation.spage20169
dc.citation.epage20208
dc.identifier.wos000345529200050
dc.identifier.doi10.3390/ijms151120169
dc.citation.rankM21
dc.identifier.pmid25380523
dc.identifier.scopus2-s2.0-84908587484
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/13514/56.pdf


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