Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries
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Petrovic, S.Takic, M.
Arsic, A.
Vučić, Vesna
Drakulić, Dunja R.
Milošević, Maja
Glibetić, Marija
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The effects of 8-days treatment with 17 alpha-estradiol (33.3 mu g/kg) and progesterone (1.7 mg/kg) on plasma lipids and fatty acid composition of plasma phospholipids were examined in intact (INT) and bilaterally common carotid arteries occluded (BCO) male Wistar rats. Significant decrease of triglyceride level was found in BCO rats after the estradiol treatment. Both hormones elevated proportion of 18:1n-7 fatty acid in INT, but they failed to have such an effect in BCO. Estradiol increased 22:5n-3 and total n-3 polyunsaturated fatty acids (PUFA) in intact, and decreased 18:2n-6 in BCO rats. Significantly lower level of total n-3 was found in progesterone-treated than in estradiol-treated BCO rats. Given that n-3 PUFA have many beneficial effects on cell and tissue function, while n-6 PUFA have mostly the opposite effects, estradiol, rather than progesterone, was seen to improve plasma lipids and phospholipids FA profiles in INT and BCO animals. Estradiol significantly elevated the e...stimated activity of Delta 9-desaturases and progesterone of Delta 5-desaturase in BCO group, with no effects in INT rats.
Keywords:
Estradiol / Progesterone / Male rats / Plasma lipids / Fatty acidsSource:
Physiological Research, 2014, 63, 3, 331-339Funding / projects:
- Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
- Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals (RS-MESTD-Basic Research (BR or ON)-173044)
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VinčaTY - JOUR AU - Petrovic, S. AU - Takic, M. AU - Arsic, A. AU - Vučić, Vesna AU - Drakulić, Dunja R. AU - Milošević, Maja AU - Glibetić, Marija PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6095 AB - The effects of 8-days treatment with 17 alpha-estradiol (33.3 mu g/kg) and progesterone (1.7 mg/kg) on plasma lipids and fatty acid composition of plasma phospholipids were examined in intact (INT) and bilaterally common carotid arteries occluded (BCO) male Wistar rats. Significant decrease of triglyceride level was found in BCO rats after the estradiol treatment. Both hormones elevated proportion of 18:1n-7 fatty acid in INT, but they failed to have such an effect in BCO. Estradiol increased 22:5n-3 and total n-3 polyunsaturated fatty acids (PUFA) in intact, and decreased 18:2n-6 in BCO rats. Significantly lower level of total n-3 was found in progesterone-treated than in estradiol-treated BCO rats. Given that n-3 PUFA have many beneficial effects on cell and tissue function, while n-6 PUFA have mostly the opposite effects, estradiol, rather than progesterone, was seen to improve plasma lipids and phospholipids FA profiles in INT and BCO animals. Estradiol significantly elevated the estimated activity of Delta 9-desaturases and progesterone of Delta 5-desaturase in BCO group, with no effects in INT rats. T2 - Physiological Research T1 - Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries VL - 63 IS - 3 SP - 331 EP - 339 UR - https://hdl.handle.net/21.15107/rcub_vinar_6095 ER -
@article{ author = "Petrovic, S. and Takic, M. and Arsic, A. and Vučić, Vesna and Drakulić, Dunja R. and Milošević, Maja and Glibetić, Marija", year = "2014", abstract = "The effects of 8-days treatment with 17 alpha-estradiol (33.3 mu g/kg) and progesterone (1.7 mg/kg) on plasma lipids and fatty acid composition of plasma phospholipids were examined in intact (INT) and bilaterally common carotid arteries occluded (BCO) male Wistar rats. Significant decrease of triglyceride level was found in BCO rats after the estradiol treatment. Both hormones elevated proportion of 18:1n-7 fatty acid in INT, but they failed to have such an effect in BCO. Estradiol increased 22:5n-3 and total n-3 polyunsaturated fatty acids (PUFA) in intact, and decreased 18:2n-6 in BCO rats. Significantly lower level of total n-3 was found in progesterone-treated than in estradiol-treated BCO rats. Given that n-3 PUFA have many beneficial effects on cell and tissue function, while n-6 PUFA have mostly the opposite effects, estradiol, rather than progesterone, was seen to improve plasma lipids and phospholipids FA profiles in INT and BCO animals. Estradiol significantly elevated the estimated activity of Delta 9-desaturases and progesterone of Delta 5-desaturase in BCO group, with no effects in INT rats.", journal = "Physiological Research", title = "Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries", volume = "63", number = "3", pages = "331-339", url = "https://hdl.handle.net/21.15107/rcub_vinar_6095" }
Petrovic, S., Takic, M., Arsic, A., Vučić, V., Drakulić, D. R., Milošević, M.,& Glibetić, M.. (2014). Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries. in Physiological Research, 63(3), 331-339. https://hdl.handle.net/21.15107/rcub_vinar_6095
Petrovic S, Takic M, Arsic A, Vučić V, Drakulić DR, Milošević M, Glibetić M. Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries. in Physiological Research. 2014;63(3):331-339. https://hdl.handle.net/21.15107/rcub_vinar_6095 .
Petrovic, S., Takic, M., Arsic, A., Vučić, Vesna, Drakulić, Dunja R., Milošević, Maja, Glibetić, Marija, "Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries" in Physiological Research, 63, no. 3 (2014):331-339, https://hdl.handle.net/21.15107/rcub_vinar_6095 .