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dc.creatorJešić, Snežana
dc.creatorJotić, Ana
dc.creatorTomanovic, Nada
dc.creatorŽivković, Maja
dc.creatorKolaković, Ana
dc.creatorStanković, Aleksandra
dc.date.accessioned2018-03-02T00:13:45Z
dc.date.available2018-03-02T00:13:45Z
dc.date.issued2014
dc.identifier.issn0003-4894 (print)
dc.identifier.issn1943-572X (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/6051
dc.description.abstractObjectives: The objectives were to detect and compare the expression of toll-like receptors (TLRs) 2, 4 and nuclear factor kappa B in mucosal lesions of chronic otitis. Methods: Fifty-five tissue samples obtained from children and adults operated on for otitis were investigated by semiquantitative immunohistochemical methods using polyclonal antibodies for TLR 2, 4 and NFkB. Kruskal-Wallis, Mann-Whitney, and Kendalls tau rank correlation tests were used. Results: Stronger expression of TLR2, 4 was found in inflamed mucosa than in the control for children and adults (TLR2: H = 23.86, P LT .001; TLR4: H = 22.80, P LT .001) (TLR2: H = 17.53, P LT .001; TLR4: H = 11.99, P LT .001); in cholesteatoma perimatrix compared to tubotympanic lesions in children (TLR2: H = 11.06, P = .004; TLR4: H = 10.61, P = .005) and adults (TLR2: H = 10.73, P =.013; TLR4: H = 9.65, P = .021). No differences were found in NFkB expression (H = 0.042, P = .99). Significant correlations were found for all pairs of molecules in cholesteatoma and tubotympanic mucosa of adults (TLR2, 4: P = .002, P LT .001; TLR2-NfkB: P = .032, P = .021; TLR4-NFkB: P =.035, P = .0013), only TLR4-NFkB in tubotympanic otitis of children (P = .026). Conclusions: Toll-like receptors 2, 4 and NFkB mediate inflammation in cholesteatoma and mucosal lesions of tubotympanic otitis in children and adults. Significant correlations between all pairs of molecules in all samples were detected in adults, but only TLR4-NFkB in children.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS//
dc.rightsrestrictedAccessen
dc.sourceAnnals of Otology Rhinology and Laryngologyen
dc.subjecttoll-like receptorsen
dc.subjectnuclear factor kappa Ben
dc.subjectotitisen
dc.subjecthumansen
dc.titleExpression of Toll-Like Receptors 2, 4 and Nuclear Factor Kappa B in Mucosal Lesions of Human Otitis: Pattern and Relationship in a Clinical Immunohistochemical Studyen
dc.typearticleen
dcterms.abstractТомановиц, Нада; Јотиц, Aна; Живковић Маја; Колаковић Aна; Станковић Aлександра; Јесиц, Снезана;
dc.citation.volume123
dc.citation.issue6
dc.citation.spage434
dc.citation.epage441
dc.identifier.wos000337974100010
dc.identifier.doi10.1177/0003489414527229
dc.citation.rankM23
dc.identifier.pmid24690988
dc.identifier.scopus2-s2.0-84903549085


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