Copeptin Level After Carotid Endarterectomy and Perioperative Stroke
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Autori
Maravić-Stojković, VeraLausevic-Vuk, L. J.
Obradović, Milan M.
Jovanović, Predrag
Tanaskovic, S.
Stojković, B.
Isenović, Esma R.
Radak, Đorđe J.
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We evaluated the prognostic value of copeptin levels in a cohort of surgical patients after elective carotid endarterectomy (CEA). Twenty-one patients with perioperative stroke were prospectively recruited. The diagnosis of cerebrovascular event (CVE) was confirmed by computed tomography. Additionally, 21 patients with CEA without any complications (control patients) were enrolled. Blood samples were taken within 3 hours of the symptom onset. Circulating copeptin level was significantly higher in patients with CVE when compared to controls (P = .025), and significantly higher in nonsurvivors than in survivors (P = .030) after CVE. Plasma concentrations of interleukin 6 (IL-6) and C-reactive protein (CRP) were also elevated in patients with CVE (IL-6: P = .043; CRP: P = .002). We conclude that the activation of the stress axis in patients with CEA results with copeptin elevation, but more so in patients with perioperative stroke. Copeptin may be a helpful biomarker for stroke risk asses...sment in patients after CEA.
Ključne reči:
acute stroke / biomarkers / copeptin / carotid endarterectomy / interleukin 6 / C-reactive proteinIzvor:
Angiology, 2014, 65, 2, 122-129Finansiranje / projekti:
- Karotidna bolest u Srbiji - patološka dinamika, prevencija, dijagnostika i inovativni terapijski postupci (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
- Hormonska regulacija ekspresije i aktivnosti azot oksid sintaze i natrijum-kalijumove pumpe u eksperimentalnim modelima insulinske rezistencije, dijabetesa i kardiovaskularnih poremećaja (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.1177/0003319712473637
ISSN: 0003-3197; 1940-1574
PubMed: 23378193
WoS: 000337970700007
Scopus: 2-s2.0-84891888692
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Maravić-Stojković, Vera AU - Lausevic-Vuk, L. J. AU - Obradović, Milan M. AU - Jovanović, Predrag AU - Tanaskovic, S. AU - Stojković, B. AU - Isenović, Esma R. AU - Radak, Đorđe J. PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6050 AB - We evaluated the prognostic value of copeptin levels in a cohort of surgical patients after elective carotid endarterectomy (CEA). Twenty-one patients with perioperative stroke were prospectively recruited. The diagnosis of cerebrovascular event (CVE) was confirmed by computed tomography. Additionally, 21 patients with CEA without any complications (control patients) were enrolled. Blood samples were taken within 3 hours of the symptom onset. Circulating copeptin level was significantly higher in patients with CVE when compared to controls (P = .025), and significantly higher in nonsurvivors than in survivors (P = .030) after CVE. Plasma concentrations of interleukin 6 (IL-6) and C-reactive protein (CRP) were also elevated in patients with CVE (IL-6: P = .043; CRP: P = .002). We conclude that the activation of the stress axis in patients with CEA results with copeptin elevation, but more so in patients with perioperative stroke. Copeptin may be a helpful biomarker for stroke risk assessment in patients after CEA. T2 - Angiology T1 - Copeptin Level After Carotid Endarterectomy and Perioperative Stroke VL - 65 IS - 2 SP - 122 EP - 129 DO - 10.1177/0003319712473637 ER -
@article{ author = "Maravić-Stojković, Vera and Lausevic-Vuk, L. J. and Obradović, Milan M. and Jovanović, Predrag and Tanaskovic, S. and Stojković, B. and Isenović, Esma R. and Radak, Đorđe J.", year = "2014", abstract = "We evaluated the prognostic value of copeptin levels in a cohort of surgical patients after elective carotid endarterectomy (CEA). Twenty-one patients with perioperative stroke were prospectively recruited. The diagnosis of cerebrovascular event (CVE) was confirmed by computed tomography. Additionally, 21 patients with CEA without any complications (control patients) were enrolled. Blood samples were taken within 3 hours of the symptom onset. Circulating copeptin level was significantly higher in patients with CVE when compared to controls (P = .025), and significantly higher in nonsurvivors than in survivors (P = .030) after CVE. Plasma concentrations of interleukin 6 (IL-6) and C-reactive protein (CRP) were also elevated in patients with CVE (IL-6: P = .043; CRP: P = .002). We conclude that the activation of the stress axis in patients with CEA results with copeptin elevation, but more so in patients with perioperative stroke. Copeptin may be a helpful biomarker for stroke risk assessment in patients after CEA.", journal = "Angiology", title = "Copeptin Level After Carotid Endarterectomy and Perioperative Stroke", volume = "65", number = "2", pages = "122-129", doi = "10.1177/0003319712473637" }
Maravić-Stojković, V., Lausevic-Vuk, L. J., Obradović, M. M., Jovanović, P., Tanaskovic, S., Stojković, B., Isenović, E. R.,& Radak, Đ. J.. (2014). Copeptin Level After Carotid Endarterectomy and Perioperative Stroke. in Angiology, 65(2), 122-129. https://doi.org/10.1177/0003319712473637
Maravić-Stojković V, Lausevic-Vuk LJ, Obradović MM, Jovanović P, Tanaskovic S, Stojković B, Isenović ER, Radak ĐJ. Copeptin Level After Carotid Endarterectomy and Perioperative Stroke. in Angiology. 2014;65(2):122-129. doi:10.1177/0003319712473637 .
Maravić-Stojković, Vera, Lausevic-Vuk, L. J., Obradović, Milan M., Jovanović, Predrag, Tanaskovic, S., Stojković, B., Isenović, Esma R., Radak, Đorđe J., "Copeptin Level After Carotid Endarterectomy and Perioperative Stroke" in Angiology, 65, no. 2 (2014):122-129, https://doi.org/10.1177/0003319712473637 . .