Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials
2014
Аутори
Pagano, GiovanniTalamanca, Annarita Aiello
Castello, Giuseppe
Cordero, Mario D.
d'Ischia, Marco
Gadaleta, Maria Nicola
Pallardo, Federico V.
Petrović, Sandra
Tiano, Luca
Zatterale, Adriana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
An extensive number of pathologies are associated with mitochondrial dysfunction (MDF) and oxidative stress (OS). Thus, mitochondrial cofactors termed mitochondrial nutrients (MN), such as alpha-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and L-carnitine (CARN) (or its derivatives) have been tested in a number of clinical trials, and this review is focused on the use of MN-based clinical trials. The papers reporting on MN-based clinical trials were retrieved in MedLine up to July 2014, and evaluated for the following endpoints: (a) treated diseases; (b) dosages, number of enrolled patients and duration of treatment; (c) trial success for each MN or MN combinations as reported by authors. The reports satisfying the above endpoints included total numbers of trials and frequencies of randomized, controlled studies, i.e., 81 trials testing ALA, 107 reports testing CoQ10, and 74 reports testing CARN, while only 7 reports were retrieved testing double MN associations, while no report was found ...testing a triple MN combination. A total of 28 reports tested MN associations with classical antioxidants, such as antioxidant nutrients or drugs. Combinations of MN showed better outcomes than individual MN, suggesting forthcoming clinical studies. The criteria in study design and monitoring MN-based clinical trials are discussed.
Кључне речи:
mitochondrial nutrients / mitochondrial dysfunction / oxidative stress / oxidative phosphorylation / Krebs cycleИзвор:
International Journal of Molecular Sciences, 2014, 15, 11, 20169-20208Финансирање / пројекти:
- Радиосензитивност хуманог генома (RS-MESTD-Basic Research (BR or ON)-173046)
DOI: 10.3390/ijms151120169
ISSN: 1422-0067
PubMed: 25380523
WoS: 000345529200050
Scopus: 2-s2.0-84908587484
Колекције
Институција/група
VinčaTY - JOUR AU - Pagano, Giovanni AU - Talamanca, Annarita Aiello AU - Castello, Giuseppe AU - Cordero, Mario D. AU - d'Ischia, Marco AU - Gadaleta, Maria Nicola AU - Pallardo, Federico V. AU - Petrović, Sandra AU - Tiano, Luca AU - Zatterale, Adriana PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/60 AB - An extensive number of pathologies are associated with mitochondrial dysfunction (MDF) and oxidative stress (OS). Thus, mitochondrial cofactors termed mitochondrial nutrients (MN), such as alpha-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and L-carnitine (CARN) (or its derivatives) have been tested in a number of clinical trials, and this review is focused on the use of MN-based clinical trials. The papers reporting on MN-based clinical trials were retrieved in MedLine up to July 2014, and evaluated for the following endpoints: (a) treated diseases; (b) dosages, number of enrolled patients and duration of treatment; (c) trial success for each MN or MN combinations as reported by authors. The reports satisfying the above endpoints included total numbers of trials and frequencies of randomized, controlled studies, i.e., 81 trials testing ALA, 107 reports testing CoQ10, and 74 reports testing CARN, while only 7 reports were retrieved testing double MN associations, while no report was found testing a triple MN combination. A total of 28 reports tested MN associations with classical antioxidants, such as antioxidant nutrients or drugs. Combinations of MN showed better outcomes than individual MN, suggesting forthcoming clinical studies. The criteria in study design and monitoring MN-based clinical trials are discussed. T2 - International Journal of Molecular Sciences T1 - Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials VL - 15 IS - 11 SP - 20169 EP - 20208 DO - 10.3390/ijms151120169 ER -
@article{ author = "Pagano, Giovanni and Talamanca, Annarita Aiello and Castello, Giuseppe and Cordero, Mario D. and d'Ischia, Marco and Gadaleta, Maria Nicola and Pallardo, Federico V. and Petrović, Sandra and Tiano, Luca and Zatterale, Adriana", year = "2014", abstract = "An extensive number of pathologies are associated with mitochondrial dysfunction (MDF) and oxidative stress (OS). Thus, mitochondrial cofactors termed mitochondrial nutrients (MN), such as alpha-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and L-carnitine (CARN) (or its derivatives) have been tested in a number of clinical trials, and this review is focused on the use of MN-based clinical trials. The papers reporting on MN-based clinical trials were retrieved in MedLine up to July 2014, and evaluated for the following endpoints: (a) treated diseases; (b) dosages, number of enrolled patients and duration of treatment; (c) trial success for each MN or MN combinations as reported by authors. The reports satisfying the above endpoints included total numbers of trials and frequencies of randomized, controlled studies, i.e., 81 trials testing ALA, 107 reports testing CoQ10, and 74 reports testing CARN, while only 7 reports were retrieved testing double MN associations, while no report was found testing a triple MN combination. A total of 28 reports tested MN associations with classical antioxidants, such as antioxidant nutrients or drugs. Combinations of MN showed better outcomes than individual MN, suggesting forthcoming clinical studies. The criteria in study design and monitoring MN-based clinical trials are discussed.", journal = "International Journal of Molecular Sciences", title = "Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials", volume = "15", number = "11", pages = "20169-20208", doi = "10.3390/ijms151120169" }
Pagano, G., Talamanca, A. A., Castello, G., Cordero, M. D., d'Ischia, M., Gadaleta, M. N., Pallardo, F. V., Petrović, S., Tiano, L.,& Zatterale, A.. (2014). Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials. in International Journal of Molecular Sciences, 15(11), 20169-20208. https://doi.org/10.3390/ijms151120169
Pagano G, Talamanca AA, Castello G, Cordero MD, d'Ischia M, Gadaleta MN, Pallardo FV, Petrović S, Tiano L, Zatterale A. Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials. in International Journal of Molecular Sciences. 2014;15(11):20169-20208. doi:10.3390/ijms151120169 .
Pagano, Giovanni, Talamanca, Annarita Aiello, Castello, Giuseppe, Cordero, Mario D., d'Ischia, Marco, Gadaleta, Maria Nicola, Pallardo, Federico V., Petrović, Sandra, Tiano, Luca, Zatterale, Adriana, "Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials" in International Journal of Molecular Sciences, 15, no. 11 (2014):20169-20208, https://doi.org/10.3390/ijms151120169 . .