Show simple item record

dc.creatorLabudović-Borović, Milica
dc.creatorIcevic, Ivana
dc.creatorKanacki, Zdenko
dc.creatorZikic, Dragan
dc.creatorSeke, Mariana
dc.creatorInjac, Rade
dc.creatorĐorđević, Aleksandar N.
dc.date.accessioned2018-03-02T00:02:39Z
dc.date.available2018-03-02T00:02:39Z
dc.date.issued2014
dc.identifier.issn0191-3123
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5924
dc.description.abstractCardioprotective effects of fullerenol C-60(OH)(24) nanoparticles (FNP) were investigated in pigs after a single treatment with doxorubicin (DOX). Semithin and ultrathin sections of myocardial tissue routinely prepared for transmission electron microscopy were analyzed. Extensive intracellular damage was confirmed in cardiomyocytes of DOX-treated animals. By means of ultrastructural analysis, a certain degree of parenchymal degeneration was confirmed even in animals treated with FNP alone, including both the oral and the intraperitoneal application of the substance. The cardioprotective effects of FNP in animals previously treated with DOX were recognized to a certain extent, but were not fully confirmed at the ultrastructural level. Nevertheless, the myocardial morphology of DOX-treated animals improved after the admission of FNP. Irregular orientation of myofibrils, myofibrillar disruption, intracellular edema, and vacuolization were reduced, but not completely eliminated. Reduction of these cellular alterations was achieved if FNP was applied orally 6 h prior to DOX treatment in a dose of 18 mg/kg. However, numerous defects, including the inner mitochondrial membrane and the plasma membrane disruption of certain cells persisted. In FNP/DOX-treated animals, the presence of multinuclear cells with mitosis-like figures resembling metaphase or anaphase were observed, indicating that DOX and FNP could have a complex influence on the cell cycle of cardiomyocytes. Based on this experiment, further careful increase in dosage may be advised to enhance FNP-induced cardioprotection. These investigations should, however, always be combined with ultrastructural analysis. The FNP/DOX interaction is an excellent model for the investigation of cardiomyocyte cell death and cell cycle mechanisms.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45005/RS//
dc.rightsrestrictedAccessen
dc.sourceUltrastructural Pathologyen
dc.subjectCardiomyocytesen
dc.subjectcardiotoxicityen
dc.subjectdoxorubicinen
dc.subjectfullerenol nanoparticlesen
dc.subjectmitotic figuresen
dc.titleEffects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Studyen
dc.typearticleen
dcterms.abstractЗикиц, Драган; Канацки, Зденко; Ицевиц, Ивана; Боровиц, Милица Лабудовиц; Секе Мариана; Дјордјевиц, Aлександар; Ињац, Раде;
dc.citation.volume38
dc.citation.issue2
dc.citation.spage150
dc.citation.epage163
dc.identifier.wos000332735900009
dc.identifier.doi10.3109/01913123.2013.822045
dc.citation.rankM23
dc.identifier.pmid24134482
dc.identifier.scopus2-s2.0-84896744952


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record