Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel
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Milošević, IrenaGuillot, Samuel
Tadić, Marin
Duttine, Mathieu
Duguet, Etienne
Pierzchala, Katarzyna
Sienkiewicz, Andrzej
Forro, Laszlo
Saboungi, Marie-Louise
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We have investigated drug loading and release from thermosensitive gel emulsions with external triggering by an alternating magnetic field (AMF) for on-demand drug delivery. Superparamagnetic iron oxide nanoparticles dispersed in gel emulsions were used to study the loading and release capabilities, with the stable nitroxide radical 2,2,6,6-tetramethyl-1-piperidinyloxy ( TEMPO) serving as the model drug. AMF activation gave similar results to temperature activation in a water bath at 37 degrees C, showing that the principal effect of the AMF is a temperature increase without burst release. These results suggest that the system could play an important role in the development of advanced drug delivery. (C) 2014 AIP Publishing LLC.
Source:
Applied Physics Letters, 2014, 104, 4Funding / projects:
- CNRS, French Ministry of Research and Education
DOI: 10.1063/1.4862811
ISSN: 0003-6951; 1077-3118
WoS: 000331209900091
Scopus: 2-s2.0-84893321494
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VinčaTY - JOUR AU - Milošević, Irena AU - Guillot, Samuel AU - Tadić, Marin AU - Duttine, Mathieu AU - Duguet, Etienne AU - Pierzchala, Katarzyna AU - Sienkiewicz, Andrzej AU - Forro, Laszlo AU - Saboungi, Marie-Louise PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5877 AB - We have investigated drug loading and release from thermosensitive gel emulsions with external triggering by an alternating magnetic field (AMF) for on-demand drug delivery. Superparamagnetic iron oxide nanoparticles dispersed in gel emulsions were used to study the loading and release capabilities, with the stable nitroxide radical 2,2,6,6-tetramethyl-1-piperidinyloxy ( TEMPO) serving as the model drug. AMF activation gave similar results to temperature activation in a water bath at 37 degrees C, showing that the principal effect of the AMF is a temperature increase without burst release. These results suggest that the system could play an important role in the development of advanced drug delivery. (C) 2014 AIP Publishing LLC. T2 - Applied Physics Letters T1 - Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel VL - 104 IS - 4 DO - 10.1063/1.4862811 ER -
@article{ author = "Milošević, Irena and Guillot, Samuel and Tadić, Marin and Duttine, Mathieu and Duguet, Etienne and Pierzchala, Katarzyna and Sienkiewicz, Andrzej and Forro, Laszlo and Saboungi, Marie-Louise", year = "2014", abstract = "We have investigated drug loading and release from thermosensitive gel emulsions with external triggering by an alternating magnetic field (AMF) for on-demand drug delivery. Superparamagnetic iron oxide nanoparticles dispersed in gel emulsions were used to study the loading and release capabilities, with the stable nitroxide radical 2,2,6,6-tetramethyl-1-piperidinyloxy ( TEMPO) serving as the model drug. AMF activation gave similar results to temperature activation in a water bath at 37 degrees C, showing that the principal effect of the AMF is a temperature increase without burst release. These results suggest that the system could play an important role in the development of advanced drug delivery. (C) 2014 AIP Publishing LLC.", journal = "Applied Physics Letters", title = "Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel", volume = "104", number = "4", doi = "10.1063/1.4862811" }
Milošević, I., Guillot, S., Tadić, M., Duttine, M., Duguet, E., Pierzchala, K., Sienkiewicz, A., Forro, L.,& Saboungi, M.. (2014). Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel. in Applied Physics Letters, 104(4). https://doi.org/10.1063/1.4862811
Milošević I, Guillot S, Tadić M, Duttine M, Duguet E, Pierzchala K, Sienkiewicz A, Forro L, Saboungi M. Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel. in Applied Physics Letters. 2014;104(4). doi:10.1063/1.4862811 .
Milošević, Irena, Guillot, Samuel, Tadić, Marin, Duttine, Mathieu, Duguet, Etienne, Pierzchala, Katarzyna, Sienkiewicz, Andrzej, Forro, Laszlo, Saboungi, Marie-Louise, "Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel" in Applied Physics Letters, 104, no. 4 (2014), https://doi.org/10.1063/1.4862811 . .