Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations
Нема приказа
Аутори
Pejić, Nataša D.Blagojević, Slavica M.
Sarap, Nataša
Maksimović, Jelena P.
Anić, SlobodanR.
Čupić, Željko
Kolar-Anić, Ljiljana Z.
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix.
Кључне речи:
Dushman reaction / Kinetic methods / Perturbations / PiroxicamИзвор:
Helvetica Chimica Acta, 2014, 97, 1, 47-55Финансирање / пројекти:
- Динамика нелинеарних физичкохемијских и биохемијских система са моделирањем и предвиђањем њихових понашања под неравнотежним условима (RS-MESTD-Basic Research (BR or ON)-172015)
- Нове технологије за мониторинг и заштиту животног окружења од штетних хемијских супстанци и радијационог оптерећења (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43009)
DOI: 10.1002/hlca.201300109
ISSN: 0018-019X; 1522-2675
WoS: 000330865900004
Scopus: 2-s2.0-84892760651
Колекције
Институција/група
VinčaTY - JOUR AU - Pejić, Nataša D. AU - Blagojević, Slavica M. AU - Sarap, Nataša AU - Maksimović, Jelena P. AU - Anić, SlobodanR. AU - Čupić, Željko AU - Kolar-Anić, Ljiljana Z. PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5870 AB - Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix. T2 - Helvetica Chimica Acta T1 - Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations VL - 97 IS - 1 SP - 47 EP - 55 DO - 10.1002/hlca.201300109 ER -
@article{ author = "Pejić, Nataša D. and Blagojević, Slavica M. and Sarap, Nataša and Maksimović, Jelena P. and Anić, SlobodanR. and Čupić, Željko and Kolar-Anić, Ljiljana Z.", year = "2014", abstract = "Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix.", journal = "Helvetica Chimica Acta", title = "Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations", volume = "97", number = "1", pages = "47-55", doi = "10.1002/hlca.201300109" }
Pejić, N. D., Blagojević, S. M., Sarap, N., Maksimović, J. P., Anić, SlobodanR., Čupić, Ž.,& Kolar-Anić, L. Z.. (2014). Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations. in Helvetica Chimica Acta, 97(1), 47-55. https://doi.org/10.1002/hlca.201300109
Pejić ND, Blagojević SM, Sarap N, Maksimović JP, Anić S, Čupić Ž, Kolar-Anić LZ. Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations. in Helvetica Chimica Acta. 2014;97(1):47-55. doi:10.1002/hlca.201300109 .
Pejić, Nataša D., Blagojević, Slavica M., Sarap, Nataša, Maksimović, Jelena P., Anić, SlobodanR., Čupić, Željko, Kolar-Anić, Ljiljana Z., "Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations" in Helvetica Chimica Acta, 97, no. 1 (2014):47-55, https://doi.org/10.1002/hlca.201300109 . .