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dc.creatorJovanović-Ćupić, Snežana P.
dc.creatorGlišić, Sanja
dc.creatorStanojevic, M.
dc.creatorVasiljevic, N.
dc.creatorBojić, Tijana
dc.creatorBožović, Ana M.
dc.creatorDimitrijević, Bogomir B.
dc.date.accessioned2018-03-01T23:56:53Z
dc.date.available2018-03-01T23:56:53Z
dc.date.issued2014
dc.identifier.issn0354-4664 (print)
dc.identifier.issn1821-4339 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5858
dc.description.abstractHepatitis C virus infection is the most common chronic blood-borne infection and one of the most important causes of chronic liver disease. Knowing the predictors associated with pegylated interferon/ribavirin (PEG-IFN/RBV) combination therapy response is important for evidence-based treatment recommendations. The goal of this study was to identify host and viral factors of response to PEG-IFN/RBV treatment in chronic hepatitis C genotype 1b patients. We have examined the relationship between gender, age, level of alanine aminotransferase (ALT), viral load and liver fibrosis progression on therapy response. ALT level and viral load were evaluated before starting treatment with combination therapy. The elevated levels of ALT and route of HCV transmission were found to be significantly associated with the response to therapy in HCV-infected patients. Our findings may be useful for estimating a patients likelihood Of achieving sustained viral response.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/37021/RS//
dc.rightsopenAccessen
dc.sourceArchives of biological sciencesen
dc.subjectHepatitis C virus (HCV)en
dc.subjectgenotype 1ben
dc.subject(pegylated) interferon-alfa/ribavirin and response to therapyen
dc.titleResponse Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1ben
dc.typearticleen
dcterms.abstractЈовановић-Ћупић Снежана; Димитријевић Богомир Б.; Бозовић Aна М.; Бојић Тијана; Станојевиц, М.; Глишић Сања; Васиљевиц, Н.;
dc.citation.volume66
dc.citation.issue1
dc.citation.spage193
dc.citation.epage201
dc.identifier.wos000330552400027
dc.identifier.doi10.2298/ABS1401193J
dc.citation.rankM23
dc.identifier.scopus2-s2.0-84892428705
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/13584/5854.pdf


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