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dc.creatorJoksić, Ivana
dc.creatorPetrović, Sandra
dc.creatorLeskovac, Andreja
dc.creatorFilipović, Jelena G.
dc.creatorGuc-Scekic, Marija
dc.creatorVujic, Dragana
dc.creatorJoksić, Gordana
dc.date.accessioned2018-03-01T23:51:38Z
dc.date.available2018-03-01T23:51:38Z
dc.date.issued2013
dc.identifier.issn0534-0012 (print)
dc.identifier.issn1820-6069 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5798
dc.description.abstractFanconi anemia (FA) is a rare genetically heterogeneous disease characterized by developmental abnormalities, progressive bone marrow failure, and cancer susceptibility. We examined spontaneous, diepoxybutane (DEB)-induced and radiation-induced sister chromatid exchanges (SCEs) in wholeblood lymphocyte cultures of bone marrow failure (BMF) patients including Fanconi anemia, mothers of affected individuals, and healthy controls. The baseline frequency of SCE in FA cells was similar to that observed in controls. However, in response to DEB SCE frequencies in FA patients and their mothers were significantly increased compared to both non-FA BMF families and healthy controls. In response to ionizing radiation, cells displayed increased frequency of SCE, but no differences between FA patients and non-FA BMF patients were seen. Our data confirm and expand previous findings by showing that SCE induced by DEB can be used as an adjunct diagnostic test not only for FA patients, but also for female heterozygous carriers, at least for complementation groups FANCA and FANCD2.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173046/RS//
dc.rightsopenAccessen
dc.sourceGenetika (Beograd)en
dc.subjectdiepoxybutaneen
dc.subjectFanconi anemia lymphocytesen
dc.subjectionizing radiationen
dc.subjectsister chromatid exchangeen
dc.titleEnhanced Frequency of Sister Chromatid Exchanges Induced By Diepoxybutane Is Specific Characteristic of Fanconi Anemia Cellular Phenotypeen
dc.typearticleen
dcterms.abstractЈоксић Ивана; Филиповиц, Јелена; Гуц-Сцекиц, Марија; Вујиц, Драгана; Јоксић Гордана; Лесковац Aндреја; Петровић, Сандра;
dc.citation.volume45
dc.citation.issue2
dc.citation.spage393
dc.citation.epage403
dc.identifier.wos000328504900010
dc.identifier.doi10.2298/GENSR1302393J
dc.citation.rankM23
dc.identifier.scopus2-s2.0-84891503632
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/13558/5794.pdf


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