Interactions of Platinum and Ruthenium Coordination Complexes with Pancreatic Phospholipase A(2) and Phospholipids Investigated by MALDI TOF Mass Spectrometry
Апстракт
Phospholipase A(2) is involved in propagation of inflammatory processes and carcinogenesis through its role in phospholipid metabolism, and release of arachidonic acid and lysophospholipids. Recent findings on correlation between elevated PLA(2) activity and metastatic cancer render this enzyme an attractive target for cancer therapy. On the other hand, due to a broad range of oxidation states under physiological conditions and a high affinity for protein binding, platinum and ruthenium coordination complexes are promising candidates for PLA(2) inhibitors. In this article, we discuss the interactions of Pt and Ru coordination complexes with PLA(2) and phospholipids, as well as the application of MALDI-TOF mass spectrometry for screening PLA(2) inhibitors. Owing to the ability of this technique to simultaneously detect and monitor changes in substrate and product concentrations, the inhibitor mechanisms of both Pt and Ru complexes with various ligands were determined.
Кључне речи:
Platinum complexes / Ruthenium complexes / Inhibitors / Phospholipids / Mass spectrometry / Phospholipase AИзвор:
Chemistry and Biodiversity, 2013, 10, 11, 1972-1986Финансирање / пројекти:
- Ministry of Sciences and Technological Development of the Republic of Serbia [127011], German Academic Exchange Service
DOI: 10.1002/cbdv.201300141
ISSN: 1612-1872; 1612-1880
PubMed: 24243606
WoS: 000328321900003
Scopus: 2-s2.0-84887931497
Колекције
Институција/група
VinčaTY - JOUR AU - Kamceva, Tina AU - Radisavljević, Maja AU - Vukićević, Iva A. AU - Arnhold, Juergen AU - Petković, Marijana PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5790 AB - Phospholipase A(2) is involved in propagation of inflammatory processes and carcinogenesis through its role in phospholipid metabolism, and release of arachidonic acid and lysophospholipids. Recent findings on correlation between elevated PLA(2) activity and metastatic cancer render this enzyme an attractive target for cancer therapy. On the other hand, due to a broad range of oxidation states under physiological conditions and a high affinity for protein binding, platinum and ruthenium coordination complexes are promising candidates for PLA(2) inhibitors. In this article, we discuss the interactions of Pt and Ru coordination complexes with PLA(2) and phospholipids, as well as the application of MALDI-TOF mass spectrometry for screening PLA(2) inhibitors. Owing to the ability of this technique to simultaneously detect and monitor changes in substrate and product concentrations, the inhibitor mechanisms of both Pt and Ru complexes with various ligands were determined. T2 - Chemistry and Biodiversity T1 - Interactions of Platinum and Ruthenium Coordination Complexes with Pancreatic Phospholipase A(2) and Phospholipids Investigated by MALDI TOF Mass Spectrometry VL - 10 IS - 11 SP - 1972 EP - 1986 DO - 10.1002/cbdv.201300141 ER -
@article{ author = "Kamceva, Tina and Radisavljević, Maja and Vukićević, Iva A. and Arnhold, Juergen and Petković, Marijana", year = "2013", abstract = "Phospholipase A(2) is involved in propagation of inflammatory processes and carcinogenesis through its role in phospholipid metabolism, and release of arachidonic acid and lysophospholipids. Recent findings on correlation between elevated PLA(2) activity and metastatic cancer render this enzyme an attractive target for cancer therapy. On the other hand, due to a broad range of oxidation states under physiological conditions and a high affinity for protein binding, platinum and ruthenium coordination complexes are promising candidates for PLA(2) inhibitors. In this article, we discuss the interactions of Pt and Ru coordination complexes with PLA(2) and phospholipids, as well as the application of MALDI-TOF mass spectrometry for screening PLA(2) inhibitors. Owing to the ability of this technique to simultaneously detect and monitor changes in substrate and product concentrations, the inhibitor mechanisms of both Pt and Ru complexes with various ligands were determined.", journal = "Chemistry and Biodiversity", title = "Interactions of Platinum and Ruthenium Coordination Complexes with Pancreatic Phospholipase A(2) and Phospholipids Investigated by MALDI TOF Mass Spectrometry", volume = "10", number = "11", pages = "1972-1986", doi = "10.1002/cbdv.201300141" }
Kamceva, T., Radisavljević, M., Vukićević, I. A., Arnhold, J.,& Petković, M.. (2013). Interactions of Platinum and Ruthenium Coordination Complexes with Pancreatic Phospholipase A(2) and Phospholipids Investigated by MALDI TOF Mass Spectrometry. in Chemistry and Biodiversity, 10(11), 1972-1986. https://doi.org/10.1002/cbdv.201300141
Kamceva T, Radisavljević M, Vukićević IA, Arnhold J, Petković M. Interactions of Platinum and Ruthenium Coordination Complexes with Pancreatic Phospholipase A(2) and Phospholipids Investigated by MALDI TOF Mass Spectrometry. in Chemistry and Biodiversity. 2013;10(11):1972-1986. doi:10.1002/cbdv.201300141 .
Kamceva, Tina, Radisavljević, Maja, Vukićević, Iva A., Arnhold, Juergen, Petković, Marijana, "Interactions of Platinum and Ruthenium Coordination Complexes with Pancreatic Phospholipase A(2) and Phospholipids Investigated by MALDI TOF Mass Spectrometry" in Chemistry and Biodiversity, 10, no. 11 (2013):1972-1986, https://doi.org/10.1002/cbdv.201300141 . .