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dc.creatorŽivković, Maja
dc.creatorŽivotić, Ivan
dc.creatorDinčić, Evica
dc.creatorStojković, Ljiljana S.
dc.creatorVojinovic, Slobodan
dc.creatorStanković, Aleksandra
dc.date.accessioned2018-03-01T23:49:18Z
dc.date.available2018-03-01T23:49:18Z
dc.date.issued2013
dc.identifier.issn0022-510X
dc.identifier.issn1878-5883
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/5771
dc.description.abstractBackground: Multiple sclerosis (MS) occurs as a result of interaction between genetic and environmental factors. Recent data support the view that oxidative damage is one of an early event in MS tissue injury. The safe elimination of reactive oxygen species and toxins via glutathione S-transferase (GST) pathways is required in order to protect cells against reactive oxygen-induced damage. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the susceptibility and clinical parameters of MS, in 455 consecutive patients and 366 controls. Methods: A multiplex polymerase chain reaction (PCR) was used to detect the deletions in GSTM1 and GSTT1 genes. Results: Patients with MS had significantly higher frequency of GSTT1 null genotype compared to controls (37.36% vs. 21.86%, respectively, p LT 0.0001, adjusted OR 2.13 (1.56-2.90)), as well as double deletions (15.38% vs. 10.38%, respectively, p LT 0.05). The carriers of GSTM1 deletion had significantly earlier onset of MS compared to the wild-type carriers (28.31 +/- 8.45 vs. 30.64 +/- 9.30 years, respectively, p = 0.03). Conclusion: This study suggests the potential pathogenic role of GSTT1 deletion on MS susceptibility. There are no similar data published so far, yet this study should be replicated in other populations. (C) 2013 Elsevier B.V. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS//
dc.rightsrestrictedAccessen
dc.sourceJournal of the Neurological Sciencesen
dc.subjectGlutathione S-transferase T1en
dc.subjectGlutathione S-transferase M1en
dc.subjectAntioxidant defenseen
dc.subjectGene polymorphismen
dc.subjectDeletionen
dc.subjectMultiple sclerosisen
dc.titleThe glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosisen
dc.typearticleen
dcterms.abstractДинциц, Евица; Станковић Aлександра; Стојковић Љиљана; Војиновиц, Слободан; Животић Иван; Живковић Маја;
dc.citation.volume334
dc.citation.issue1-2
dc.citation.spage6
dc.citation.epage9
dc.identifier.wos000327674800002
dc.identifier.doi10.1016/j.jns.2013.07.001
dc.citation.rankM22
dc.identifier.pmid23932298
dc.identifier.scopus2-s2.0-84887493190


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