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dc.creatorSimić, Iva
dc.creatorAdžić, Miroslav
dc.creatorMaric, Nadja
dc.creatorSavić, Danka A.
dc.creatorĐorđević, Jelena D.
dc.creatorMihaljevic, Marina
dc.creatorMitić, Miloš
dc.creatorPavlovic, Zorana
dc.creatorSoldatovic, Ivan
dc.creatorKrstic-Demonacos, Marija
dc.creatorJasovic-Gasic, Miroslava
dc.creatorRadoičić, Marija B.
dc.date.accessioned2018-03-01T23:47:43Z
dc.date.available2018-03-01T23:47:43Z
dc.date.issued2013
dc.identifier.issn0165-1781 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5753
dc.description.abstractThe mechanism of maladaptive chronic stress response involves altered phosphorylation of the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic vulnerability factors, such as neuroticism and self-reports of negative affective states, may be associated with alterations in levels of the GR and GR phosphoisoforms in peripheral blood mononuclear cells (PBMC) of healthy adults. In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression. Also, we assessed plasma cortisol levels in all tested subjects. Our results showed that in women nuclear pGR-S226 was positively correlated with neuroticism and current reports of depression, anxiety and stress, while the ratio of nuclear pGR-S211/pGR-S226 was negatively correlated with reports of depression. None of the aforementioned correlations were significant in men. No significant relations between cortisol levels and any of GR parameters were observed. These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41029/RS//
dc.rightsrestrictedAccessen
dc.sourcePsychiatry Researchen
dc.subjectGlucocorticoid receptor phosphorylationen
dc.subjectNeuroticismen
dc.subjectDepressionen
dc.subjectAnxietyen
dc.subjectStressen
dc.subjectHealthy populationen
dc.titleA preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adultsen
dc.typearticleen
dcterms.abstractКрстиц-Демонацос, Марија; Симиц, Ива; Радоичић Марија; Мариц, Надја; Aджић Мирослав; Савић Данка A; Михаљевиц, Марина; Павловиц, Зорана; Ђорђевић Јелена Д.; Митић Милош; Јасовиц-Гасиц, Мирослава; Солдатовиц, Иван;
dc.citation.volume209
dc.citation.issue3
dc.citation.spage658
dc.citation.epage664
dc.identifier.wos000326766300063
dc.identifier.doi10.1016/j.psychres.2013.02.002
dc.citation.rankM22
dc.identifier.pmid23477901
dc.identifier.scopus2-s2.0-84885478388


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