Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels
Апстракт
Silver nanoparticles were fabricated via in situ reduction of silver nitrate embedded in swollen P(HEMA/IA) hydrogel, using gamma radiolysis method. Copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), previously synthesised by gamma radiation for wound dressing application, were used as a carrier and a stabilising agent, while ethyl alcohol was used as a free radical scavenger. The influence of different P(HEMA/IA) hydrogels and silver salt concentrations on the size and distribution of nanoparticles was investigated. The Ag/P(HEMA/IA) nanocomposites were characterised by high resolution scanning electron microscopy, energy dispersive spectroscopy, wide-angle X-ray diffraction, UV-Vis spectroscopy and swelling measurements. Escherichia coli (Gram-negative bacterium), Staphylococcus aureus (Gram-positive bacterium) and Candida albicans (fungus) were used to prove the antimicrobial properties of Ag/P(HEMA/IA) nanocomposites. The inhibition kinetics o...f bacteria growth was investigated by measuring the colony-forming unit. The antimicrobial effectiveness of the Ag/P(HEMA/IA) hydrogel nanocomposite was demonstrated even at small silver concentrations. P(HEMA/IA) hydrogels containing nanosilver particles was found suitable to be used as wound dressing.
Кључне речи:
Ag nanoparticles (AgNPs) / Gamma radiation / P(HEMA/IA) hydrogel / Antimicrobial activityИзвор:
Polymer Bulletin, 2013, 70, 12, 3347-3357Финансирање / пројекти:
- Хемијско и структурно дизајнирање наноматеријала за примену у медицини и инжењерству ткива (RS-172026)
DOI: 10.1007/s00289-013-1026-9
ISSN: 0170-0839; 1436-2449
WoS: 000325774400008
Scopus: 2-s2.0-84886085710
Колекције
Институција/група
VinčaTY - JOUR AU - Mićić, Maja M. AU - Milić-Vukašinović, Tanja AU - Mitrić, Miodrag AU - Jokić, Bojan M. AU - Suljovrujić, Edin H. PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5718 AB - Silver nanoparticles were fabricated via in situ reduction of silver nitrate embedded in swollen P(HEMA/IA) hydrogel, using gamma radiolysis method. Copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), previously synthesised by gamma radiation for wound dressing application, were used as a carrier and a stabilising agent, while ethyl alcohol was used as a free radical scavenger. The influence of different P(HEMA/IA) hydrogels and silver salt concentrations on the size and distribution of nanoparticles was investigated. The Ag/P(HEMA/IA) nanocomposites were characterised by high resolution scanning electron microscopy, energy dispersive spectroscopy, wide-angle X-ray diffraction, UV-Vis spectroscopy and swelling measurements. Escherichia coli (Gram-negative bacterium), Staphylococcus aureus (Gram-positive bacterium) and Candida albicans (fungus) were used to prove the antimicrobial properties of Ag/P(HEMA/IA) nanocomposites. The inhibition kinetics of bacteria growth was investigated by measuring the colony-forming unit. The antimicrobial effectiveness of the Ag/P(HEMA/IA) hydrogel nanocomposite was demonstrated even at small silver concentrations. P(HEMA/IA) hydrogels containing nanosilver particles was found suitable to be used as wound dressing. T2 - Polymer Bulletin T1 - Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels VL - 70 IS - 12 SP - 3347 EP - 3357 DO - 10.1007/s00289-013-1026-9 ER -
@article{ author = "Mićić, Maja M. and Milić-Vukašinović, Tanja and Mitrić, Miodrag and Jokić, Bojan M. and Suljovrujić, Edin H.", year = "2013", abstract = "Silver nanoparticles were fabricated via in situ reduction of silver nitrate embedded in swollen P(HEMA/IA) hydrogel, using gamma radiolysis method. Copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), previously synthesised by gamma radiation for wound dressing application, were used as a carrier and a stabilising agent, while ethyl alcohol was used as a free radical scavenger. The influence of different P(HEMA/IA) hydrogels and silver salt concentrations on the size and distribution of nanoparticles was investigated. The Ag/P(HEMA/IA) nanocomposites were characterised by high resolution scanning electron microscopy, energy dispersive spectroscopy, wide-angle X-ray diffraction, UV-Vis spectroscopy and swelling measurements. Escherichia coli (Gram-negative bacterium), Staphylococcus aureus (Gram-positive bacterium) and Candida albicans (fungus) were used to prove the antimicrobial properties of Ag/P(HEMA/IA) nanocomposites. The inhibition kinetics of bacteria growth was investigated by measuring the colony-forming unit. The antimicrobial effectiveness of the Ag/P(HEMA/IA) hydrogel nanocomposite was demonstrated even at small silver concentrations. P(HEMA/IA) hydrogels containing nanosilver particles was found suitable to be used as wound dressing.", journal = "Polymer Bulletin", title = "Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels", volume = "70", number = "12", pages = "3347-3357", doi = "10.1007/s00289-013-1026-9" }
Mićić, M. M., Milić-Vukašinović, T., Mitrić, M., Jokić, B. M.,& Suljovrujić, E. H.. (2013). Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels. in Polymer Bulletin, 70(12), 3347-3357. https://doi.org/10.1007/s00289-013-1026-9
Mićić MM, Milić-Vukašinović T, Mitrić M, Jokić BM, Suljovrujić EH. Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels. in Polymer Bulletin. 2013;70(12):3347-3357. doi:10.1007/s00289-013-1026-9 .
Mićić, Maja M., Milić-Vukašinović, Tanja, Mitrić, Miodrag, Jokić, Bojan M., Suljovrujić, Edin H., "Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels" in Polymer Bulletin, 70, no. 12 (2013):3347-3357, https://doi.org/10.1007/s00289-013-1026-9 . .